Buntanetap - a trial participant feedback

[Farooqji]

Written after watching the Annovis webinar on the Parkinson’s Trial results:

I participated in the trial at the Ohio State University from January 2023 through July 2023. During the six months I was taking buntanetap, I saw significant improvement in my symptoms.

Let me start with my story. I was diagnosed with young onset Parkinson’s in November of 2017. At the time, I was an 8 on the UPDRS. In January of 2022, I was at a 32 and I started levodopa. This brought me back to an 18 which was better but I still struggled with rigidity and bradykinesia. The disease was starting to show signs on my left side (I started on my dominant, right side). Within a few months of starting buntanetap, I began to feel better and move better. At the end of the trial, my research nurse and NP told me I was “below 10.” Six months later, six months after I was finished with the trial, I had a routine visit with my movement NP and I was a SIX - better than I was at diagnosis!!!!! And my physical therapist who I would see every six months just to be evaluated told me I was walking better and faster than many of her neurotypical patients! One year after the trial ended for me, at my most recent 6-month neuro check-up, my NP got me at a THREE!!!

What did buntanetap did do for me?

~I felt better physically than I had in years

~The left side disease progression was essentially gone

~Colleagues told me that I was walking better than I had in years and they couldn’t even tell I had Parkinson’s anymore

~I got my arm swing back after losing it in 2015!!!!!

~My right hand tap test is much better than it was - in fact, at my most recent appointment, my NP marked it as a 0 (normal!!!)

~I could once again do things that required fine motor skills

~My right foot stopped dropping and tripping me

~I can easily get out of a chair now

During and since the trial, I’ve traveled to Europe for the first time in my life (one day while there, we walked 33,000 steps!), traveled to Minnesota to visit my son and see a Vikings game, regained energy to be fully present while teaching, been able to actively enjoy my children, and got married. I have regained my life; my life became more about living and less about the disease. Because of buntanetap, I’ve been able to push Parkinson’s back, be me again, and LIVE!

x.com/EllenStadler/status/1...

[Zscaleplanet]

Why do I feel like this is an “infomercial” for Buntanetap? Color me skeptical….

[Farooqji in reply to Zscaleplanet]

God knows better

[WinnieThePoo in reply to Zscaleplanet]

Because apparently you improve more when you stop taking buntanetap, and updrs numbers don't work like that. Among other reasons

[limcheeese22]

do you know what dosage you were on?

[WinnieThePoo in reply to limcheeese22]

Nil for the last 12 months and 20 updrs points

[limcheeese22 in reply to WinnieThePoo]

I mean the trial dosage of buntanetap 10 mg, 20 mg or placebo?

[WinnieThePoo in reply to limcheeese22]

I realise. But this very questionable piece of nonsense describes more improvement after stopping the drug than while taking it. So whatever the trial dose was, the best dose was nothing.It may be this person has a vivid imagination.

[Zscaleplanet in reply to WinnieThePoo]

…… or maybe this Ellen Stadler doesn’t even exist. Most likely she’s a figment (or a creation) of the imagination of one of the many angry Annovis Bio investors that create fake accounts on this forums, just to pump their stock.

And looking on X at the actual so-called “endorsement”, Annovis Bio is mentioned at the top and bottom of this canard.

[limcheeese22 in reply to WinnieThePoo]

So you don’t know yet? I hope you were on the 20 mg group That makes sense .

Ps I am a investor and patient I hope the drug works badly

[Farooqji in reply to limcheeese22]

The gentleman was on 10 mg

[WinnieThePoo in reply to limcheeese22]

I would love the drug to work. We need something, and the sooner the better. But we need something which actually works. Not something which makes money for investors but little or no difference for people with PD.Although we are still waiting on the bare data, the recent trial unambiguously showed the drug didn't work. Some people taking it thought it made them a bit better. But some people taking a sugar pill also thought that made them feel better. The drug did no better than the sugar pill.

Maybe it was the wrong trial. Maybe a better trial would show it works in some identifiable limited circumstances

Or maybe it just doesn't work

[Buckholt in reply to WinnieThePoo]

If this was a genuine breakthrough, it would be all over the general media and the researchers and medics involved would be very excited to tell everyone. It’s been all rather flat

[Parked in reply to WinnieThePoo]

placebo effect maybe?

[limcheeese22]

joined 2013 not a new account. Hopefully it is real

[acceptanceand]

Hi Farooqji,

Is your post related to your personal experience on Buntanetap?

Tony

[acceptanceand in reply to acceptanceand]

Sorry, reread the post and you have said that the feedback is from a trial participant. 🧐

[Farooqji in reply to acceptanceand]

This isn't my experience. I have quoted a gentleman who shared his experience on twitter. I have also shared the twitter link

[Zscaleplanet in reply to Farooqji]

It’ s not a gentleman quoted, but a woman - who by the way has very little internet presence that I can see, although I don’t have Facebook or an X account. It’s rather suspicious.

[Farooqji in reply to Zscaleplanet]

Thanks for correction

[Farooqji in reply to Zscaleplanet]

I have checked all of her posts on twitter since her joining the twitter in 2012. In 2017 she had told about her PD. In my opinion she is definitely PD patient however I can't say anything about her feedback on buntanetap (whether it's real or annovis has bribed her 😂)

Twitter profile

[acceptanceand]

From ChatGPT4 just now…

Buntanetap has shown promising results in recent clinical trials for the treatment of Alzheimer's and Parkinson's diseases. In Phase 2 and Phase 3 trials, buntanetap demonstrated significant improvements in cognitive function for Alzheimer's patients and motor function for Parkinson's patients.

For Parkinson's disease, buntanetap also showed positive results in a Phase 3 trial. Patients treated with the drug experienced improvements in motor and cognitive functions, as well as a reduction in the toxic protein levels associated with the disease. The trial had a high completion rate, suggesting good tolerability and safety [oai_citation:4,Phase 2/3 trial data of buntanetap for Alzheimer's expected in March 2024 | Buntanetap being tested in early Parkinson's patients in Phase 3 trial | Alzheimer's News Today](alzheimersnewstoday.com/new... [oai_citation:5,Phase 3 trial of buntanetap for early-stage Parkinson’s nears end](parkinsonsnewstoday.com/new....

Given these outcomes, Annovis Bio, the developer of buntanetap, plans to continue with further trials, including long-term studies to confirm these results and potentially bring the drug to market [oai_citation:6,Annovis Bio’s Buntanetap Found Safe and Effective in](globenewswire.com/news-rele... [oai_citation:7,Buntanetap Safe, Effective in Phase 2a Trial; Annovis Plans More | Alzheimer's News Today](alzheimersnewstoday.com/new... [oai_citation:8,Phase 2/3 trial data of buntanetap for Alzheimer's expected in March 2024 | Buntanetap being tested in early Parkinson's patients in Phase 3 trial | Alzheimer's News Today](alzheimersnewstoday.com/new....

[Pixelpixie]

so happy for you. I was on the low dose and saw no change or improvement

[MarionP]

I listened to the most recent company update conference call about 2-3 weeks ago... In which they expressed some disappointment at the results and spoke of their desire to therefore seek permission from FDA to do a longer, 18-month trial k and hopefully including using the current shorter-term data to see if longer-term data (18 months) would show better results and rescue the disappointing current trial's result.