"There is already more than enough dopamine inside the cells. In some ways, using dopaminergic therapies is akin to whipping a tired horse; it helps for a few strides but doesn't affect long-term results."
"Four laboratory studies report that blocking production of dopamine within these brain cells improves cell function and keeps them alive. Such data in the context of this new observation of increased intracellular dopamine establish a new therapeutic path – one that reduces the average level of dopamine in the nerve cells, while preserving the cells' ability to synthesize dopamine when needed."
*"This approach can be tested now by using the drug metyrosine to partially block the synthesis of dopamine within the nerve cells."
"We've lived in the dopaminergic era since the 1970s and that has allowed for millions of people with Parkinson's to feel some improvement in their symptoms. But the disease worsens inexorably. It's time to test a new approach, one based on firm science as highlighted by this groundbreaking publication. The clinical trial to assess the potential impact of blocking dopamine could start this year." Source: prnewswire.com/news-release...