When first diagnosed by my primary care physician he prescribed Sinemet CR 25/100 to be taken at 6 hour intervals 4 times daily , today I met with a Neurologist/Parkinson’s movement disorder specialist, she changed my regiment to the quick release Sinemet 25/100 three times daily at 5 hour intervals beginning at 7am and a 25/100 extended release tab atm bedtime.
Thoughts on this regiment…Anyone doing something similar ?
It is what works best for you that counts.
I am also a believer in not fixing that which is not broken.
Always solid advice…the new cocktail stars tomorrow morning, I’ll report my experience in a few days. Thanks PB
hi OP ! how's it going? did the new regimen help or set you back?
Honestly, I didn’t see a drastic change in on/off periods…you just have to tweak your dosage intervals until of f periods are minimized, easier said than done.
I use 1 1/2 tab Sinemet 10/100 4 t/day and I take 2 100/25CR before bedtime
Hi, I used to take both. I took regular Sinemet 25-100 every 4 hours from 7:00 a.m. to 7:00 p.m. and Sinemet CR at 11:00 p.m. The CR was to help me manage when I got up to use the bathroom in the middle of the night. It worked well. I now take Rytary instead of Sinemet to ostensibly help with my dyskinesias and I also take Rytalry in the middle of the night since it is extended release. The only Sinemet I take now is the fast release for acute off periods. Rytary is okay but it takes 2 hours for it to kick in I'm not kidding so I sometimes wish I was still taking Sinemet.
I took 1 25/100 IR together with one 26/100 CR which helped extend my ON time. When OFF appeared again, I am giving Rytary a try.
Still adjusting dose. Too much in the morning made me impulsive. Too little in the afternoon gives me an awful mid afternoon slump ( halfway between doses)..
I found taking the CR/IR combo for my evening dose works better than Rytary for me, as too much dopamine was interfering with my sleep and I was getting too much dopamine causing pretty severe wearing off dyskinesia right before bed brushing teeth ( dopamine not being broken down adequately, I think. I’m not that good at the pharmacokinetics part).
I was only prescribed 145s, but asked for 95s as well to be able to more easily adjust the dose…
my neurologist advised me to take one or two cr tablets at night,during the day i take vsinemet 100/25 1+1/2 five tines daily every three hours, works for me ,I am 84 yrs young,
U
Thanks to everyone for the feedback…this is clearly a case of what the bear said, go with what ya know works best for you.
There’s clearly no set standard for a PD meds regiment, it’s a listen to your body kinda deal and adjust as necessary.
Thanks again everyone, hope you’re all having a good day.
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