List of most rich sources of GDNF

[Farooqji]

Here is the list

drive.google.com/open?id=1_...

Interestingly Rasagiline, Selegiline, Naringin (found in the grapefruit ) and ibogaine are among the top GDNF producers

I am already taking ibogaine, considering to add grapefruit extract as well

[Farooqji]

nrronline.org/article.asp?i...

[park_bear]

According to animal studies naringin itself is neuroprotective. It is available as a supplement. I tried it and found it irritating to my stomach.

[wifeofparky]

I read the study iqbaliqbal referenced on Naringin and it was administered by an injection not orally. Grapefruit can enhance or minimize the effect of many drugs. I would be very careful about taking grapefruit extract unless you are sure it will not effect the absorption of your meds

[M_rosew]

I am a pwp on medication. I have been advised not to touch grapefruit in any form.

[ruff1]

My husband has also been told not to touch grapefruit with his medication x

[Farooqji in reply to ruff1]

why

[danfitz in reply to Farooqji]

Grapefruit contains a substance which prevents some medications from breaking down so the medication builds up in the body.

[Dap1948]

You may be interested in Brant Cortright's book Neurogenisis, diet and lifestyle. He lists foods good for increasing BDNF and GDNF

[Autumn56 in reply to Dap1948]

What is GDNF? Anyone?

[Dap1948 in reply to Autumn56]

GDNF....Glial derived neurotrophic factors. Neurotrophic factor that enhances survival and morphological differentiation of doperminergic neurons and increases their high-affinity dopermine uptake. Good stuff to have I think!

[felixned]

Iqbaliqbal, how is your ibogain experiment going? Any symptomatic improvement? Do you still experience the feeling of well being? If so do you sleep better? Thanks.

[Farooqji in reply to felixned]

I was feeling 80 % symptoms free after initial 5 days of use. Then I took 3 days break ( just experimentally) to see the difference. Unfortunately I could not regain the initial improvements even after resuming the dose 8 days ago. The pause broke the momentum and I am lamenting it

[danfitz in reply to Farooqji]

This just seems so odd to me. I wonder what causes this. I would have thought that you would be back to where you were after a resumption that is longer than the initial dosing period. Have decided what to try now?

[Farooqji in reply to danfitz]

I have started TA today. Will go with it for the next 3 to 4 days and if unsuccessful, will discontinue ibogaine for 1 month to reset my system

[danfitz in reply to Farooqji]

Ok. Please keep posting what is going on with you. As far as I go there has been no reoccurrence of toe curling/foot cramping other than the single mild instance that I reported. So I am suspecting it was not the TA but was because of lack of sleep or the excitement around here. Or maybe was just a foot cramp and is unrelated to PD.

[Farooqji in reply to danfitz]

Definitely I will post updates. Good to hear that TA is equally effective for you

[Kia17 in reply to danfitz]

Hi danfitz

Do you take any PD medications?

[danfitz in reply to Kia17]

Yes. I take sinemet. I have been diagnosed for 10 years and have been on sinemet the whole time.

[danfitz in reply to danfitz]

I should add that I have tried numerous supplements as well. The only one that provided significant relief was marijuana. I decided to try ibogaine when I discovered it stimulates GDNF production in the brain thereby offering the chance of remission. I try not to completely mask the tremor with sinemet because I don’t want to mask the feedback to the brain that dopamine is deficient. If the tremor becomes too annoying I quiet it with medical marijuana. But even when I use sinemet to completely mask the tremor I only have to use approximately 40% of the sinemet I needed to accomplish the same thing just a few months ago.

[Kia17 in reply to danfitz]

Thank you danfitz

[felixned]

1 month break sounds like a logical approach. Do people who sell this stuff offer any insight?

[Farooqji in reply to felixned]

They just mislead people. different suppliers advise different approaches. This is the area where the knowledge of people is extremely Limited. I am in touch with some experts on the subject they also don't have any clue. The idea of one month break is based on my own gut feeling, as this phenomenon is common with other drug too.

[danfitz in reply to Farooqji]

Plus some of them base their advice based on the use they make of ibogaine. So if they administer “flood” doses they advise based on flood dosing making no adjustment for micro dosing. When I was initially investigating ibogaine for PD one supplier recommended a 200 mg dose to start. That would be right for an initial flood dose but at least an order of magnitude too much for micro dosing. My neurologist got a good laugh out of that.

[Farooqji in reply to danfitz]

When do you have next appointment with your Neurologist. Can you ask his opinion about my case

[danfitz in reply to Farooqji]

Do you mean about the stop/restart?

[Farooqji in reply to danfitz]

yes

[danfitz in reply to danfitz]

My neurologist did not recommend ibogaine to me. I just felt I should disclose my plan to them and was surprised when they were interested and spent some time reading and commenting on some of the information I came up with. And I am certain they would not recommend ibogaine for any purpose given the state of the research. I am just lucky they are interested enough to listen and comment. It simply may be their desire to know what their patient is doing. That is good enough for me.

[Farooqji in reply to danfitz]

OK , thanks

[felixned]

iqbaliqbal, here is an interesting link that talks about various plants used to treat symptoms of PD:

jarcp.com/614-review-of-nat...

They don't mention iboga but still they offer lots of interesting data

[Farooqji in reply to felixned]

Thanks, really a good article which have described nearly every herb effective in PD. I have used most of them but iboga is something different