We recently showed that the up‐regulation of the glial cell line‐derived neurotrophic factor (GDNF) pathway in the midbrain, is the molecular mechanism by which the putative anti‐addiction drug Ibogaine mediates its desirable action of reducing alcohol consumption (1). Human reports and studies in rodents have shown that a single administration of Ibogaine results in a long‐lasting reduction of drug craving (humans) and drug and alcohol intake (rodents). Here we determine whether, and how, Ibogaine exerts its long‐lasting actions on GDNF expression and signaling. Using the dopaminergic‐like SHSY5Y cell line as a culture model, we observed that short‐term Ibogaine exposure results in a sustained increase in GDNF expression that is mediated via the induction of a long‐lasting autoregulatory cycle by which GDNF positively regulates its own expression. We show that the initial exposure of cells to Ibogaine or GDNF results in an increase in GDNF mRNA, leading to protein expression and to the corresponding activation of the GDNF signaling pathway. This, in turn, leads to a further increase in the mRNA level of the growth factor. The identification of a GDNF‐mediated, autoregulatory long‐lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases.—He, D.‐Y., Ron, D. Autoregulation of glial cell line‐derived neurotrophic factor expression: implications for the long‐lasting actions of the anti‐addiction drug, Ibogaine. FASEB J. 20, E1820 –E1827 (2006)
RESULTS
Ibogaine treatment induces a persistent increase in GDNF expression and Ret phosphorylation
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JayPwP
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Okay - this research is good as far as it goes, namely, demonstrating that Ibogaine promotes the production of GDNF in a cell culture model. This provides a theoretical basis for the reports of improvement from people with Parkinson's. Together with these reports it paints a consistent picture of the helpfulness of Ibogaine.
I am just discovering Ibogaine in my general interest in psychedelics and it is so exciting. Is access and cost the main reason why more folks with pd are not taking it? Also! Do you know if you can microdose on this while on Sinemet?
Available in Mexico. "Ibogaine is available via legal prescription in New Zealand." " Ibogaine is illegal in the US, France, Sweden, Denmark, Belgium, Poland, Croatia and Switzerland and strongly restricted in the UK under the 2016 Psychoactive Substances Act."
I have just found a source up here in Canada where the laws around psychedelics are a little more lax... there are Ibogaine clinics out in the west coast, mainly for treating addiction. There is one psychedelic research company called Mindcure that developed a synthetic ibogaine and started doing clinical research on ibogaine and parkinsons, I believe. Hoping to get my dad on these soon but just wanted to triple check that its ok to take it when on Sinemet!!
Be careful, I have heard of bad side effects and even death? Maybe this has to do with dosing but there is probably a reason you can’t get it in so many countries.
The bad effects that have been documented occur at the “flood” dose level. The regime for PD treatment is at the “micro” dose level. A typical micro dose is 5-15 mg 2X a day. Flood doses start at 200mg and go up from there. 500 mg is not uncommon for treatment of addiction for which ibogaine is a potent treatment for.
Hi Connie! I am fine. How are you? Yes, I still take ibogaine when I can obtain it. Yes, they do. They also backslide after a longish break in taking ibogaine.
Sorry. I don’t name vendors. I don’t want people to think I am one of the vultures that prey on people in our community by pushing supplements or quack machines.
hi danfitz, wondering how you consume such tiny amounts? in capsule? in water? we have some that we are wanting to my dad to try, but when we measure the powder out at 5mg (to start), its so little! thanks!
I gather from this thread and others that Ibogaine for PD is not just a six month repair job. It sounds as though it has to be maintained long-term and would end up becoming a lifelong commitment to reap the full benefits for PD symptoms.
I think you are correct. But it hard to tell. There is limited information on ibogaine and PD. Plus, there are issues with the quality of the extracts as well as procurement given ibogaine's status as a Schedule 1 drug in the US.
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Phenylethylamine is NOT Palmitoylethanolamide! They are both called PEA. I take Palmitoylethanolamide
