Acadesine for patients with relapsed/refractory (CLL). Like fludarabine but very different.

[Cllcanada]

Acadesine, , 5-aminoimidazole-4-carboxamide- 1-D-ribofuranoside or AICA-riboside, is a water soluble nucleoside with a different mechanism of action compared to currently approved nucleoside analogs (e.g., fludarabine).

Of importance...

Acadesine is not reliant on the p53 tumor suppressor or ataxia telangiectasia mutated (ATM) proteins to drive apoptosis, and hence, the absence/loss of function of these proteins in patients with CLL should not affect the activity of acadesine.

This is an important issue because alterations of either p53 or ATM are related to resistance to chemotherapy in CLL

link.springer.com/content/p...

Stay tuned...early days.

[keepfit123]

Acadesine sounds like another useful drug for CLL . Does the absence /loss of function of P.53 mean you are 17p deleted.

[Cllcanada Top Poster CURE Hero]

Yes and no...TP53 is a gene that encodes a tumor supressor protein called p53 and it is often deleted in 17p deletion...but some times it is mutated or disfunctional...it depend on the locus and size of the missing bit of chromosone...

more

asco.org/ASCOv2/Meetings/Ab...