Acadesine, , 5-aminoimidazole-4-carboxamide- 1-D-ribofuranoside or AICA-riboside, is a water soluble nucleoside with a different mechanism of action compared to currently approved nucleoside analogs (e.g., fludarabine).
Of importance...
Acadesine is not reliant on the p53 tumor suppressor or ataxia telangiectasia mutated (ATM) proteins to drive apoptosis, and hence, the absence/loss of function of these proteins in patients with CLL should not affect the activity of acadesine.
This is an important issue because alterations of either p53 or ATM are related to resistance to chemotherapy in CLL
link.springer.com/content/p...
Stay tuned...early days.