I know TP53 plays a role in diagnosing and treating CLL, but I also found that Li-Fraumeni and TP53 are related.
I was wondering if anyone here has been tested and diagnosed with Li-Fraumeni as well as CLL.
Here is additional information on Li-Fraumeni:
my.clevelandclinic.org/heal...
Li-Fraumeni syndrome happens when something changes in the TP53 gene, which contains the instruction manual to make a protein called tumor protein 53, or P53. Your P53 protein is a tumor suppressor. It keeps your cells from dividing and growing too quickly or in an uncontrolled way, becoming tumors. When your TP53 gene changes, the P53 protein instruction manual changes as well, losing the how-to section for making P53. Without properly functioning P53 proteins, cells can divide uncontrolled and become cancers.
Most people with Li-Fraumeni syndrome inherited altered TP53 genes from one or both parents. But approximately 25% of people with the syndrome were born with an altered TP53 gene.
People with Li-Fraumeni syndrome often are very sensitive to radiation, which means your cancer treatment shouldn’t include any form of radiation therapy.
People with Li-Fraumeni syndrome are sensitive to radiation. That’s why breast cancer screenings don’t call for mammograms.