Foundation One heme blood test results

[Cusube1967]

Hi, I wonder if somebody knows about this topic. My platelets have been high for six years; the bone marrow biopsy was incomplete because the nurse could not obtain the solid part. Anyway, the liquid aspiration was analyzed, and the bone marrow looked normal; the next-generation sequencing panel from the bone marrow detected the FANCE gene, then I tested negative for Fanconi Anemia, resulting in being only a carrier but not having the disease. Then my hematology ordered me a blood test called Foundation One heme. This test detected the TCL1A gene, and the report explains this gene is associated with T-prolymphocytic leukemia and T-cell chronic lymphocytic leukemia. Also, with Burki lymphoma, in which mutations have been detected in 15% of cases. High TCL1A expression has been reported in a range of B-cell diseases, including CLL, DLBCL, mantle cell lymphoma, follicular lymphoma, splenic marginal zone lymphoma, and primary cutaneous B cell lymphoma. As I mentioned, the CBC only indicates a high platelet count. Has anyone been in a similar situation or had the Mutation TCL1A before being diagnosed with leukemia?

[LeoPa]

I think I read once about a member having high platelet counts but I don't remember the details. What you described seems so complicated it would likely make experts scratch their heads to come up with correct answers.

[Indie1234]

Hi Cusube, for years I had elevated Platelets. Normally sitting between 800 or 900. It was diagnosed as Essential Thrombocythemia. That was diagnosed by a bone marrow biopsy. My Treatment was continuous Aspirin. Then about 14 yrs ago, the platelets shot down to the low hundreds and stayed there. FBC then revealed CLL. Platelets are now around 160 to 180. I am still W & W.

Indie

[Cusube1967 in reply to Indie1234]

thank you for your reply. In my case the bone marrow biopsy was normal ( January) . Platelets continue hight ( 480 to 600) . White blood cells normal . But the TCL1A mutation was detect in a liquid biopsy ( from my blood). This mutation has been detected in T cell prolymphocytic leukemia so I’m thinking I can develop the disease symptoms at any time. By the way what is the FBC ? Also can you tell me how are your white blood cell ?

[Indie1234 in reply to Cusube1967]

FBC is Full Blood Count. White cells are 68000, lymphocytes 55000

Indie. Female. Australia.

[Cusube1967 in reply to Indie1234]

Those changes in your CBC occurred without any other new symptoms?

[Cusube1967 in reply to Indie1234]

I’m sorry Indie I got it full blood count . So , how was it?

[Indie1234 in reply to Cusube1967]

White blood cells and Lymphocytes just kept increasing. I had swollen lymph nodes in my neck, and platelets came down to normal range, and have stayed normal. Hope all goes well for you.

Indie.

[Cusube1967]

thank you so much for you help Indie