Bone Marrow Biopsy showing Manoclonal B Lymphocytosis

[gsanchez]

Hello My name is Gloria,

My husband Angel has been fighting small B-Cell Lymphocytic Leukemia/lymphoma for more than 8 years and none of the chemotherapy has helped him. The only treatment that helped him was Imbrivica (Ibrutinib)for a year his blood levels improved almost to normal levels but, the only thing is that he always feeling tired, no energy any little physical activity will make him exhausted. In April his IGM count starting to climb up and now he is in ICU in very critical conditions. A Bone Marrow biopsy was performed and it shows that the cancers has transformed into Monoclonal B Lymphocytosis composing 80% of the bone marrow cellularity, with large cell features, indicative of RITCHTER transformation.

Immunophenotype:

Possitive for CD19, CD20 (DIM), CD5, CD23, Lambda light chain.

Negative for CD10, CD38, FMC7.

Lymphotosis (28,500/MCL0 with Large, atypical forms.

Any information or experience dealing with this type of transformation will help understand better.

[Hidden]

Hi gsanchez

Ritchters is currently being discussed in detail on another post by one of the sites experts cllcanada, look thru the posts or try to find him and I’m sure he can help.

Stuart

[Hidden]

There’s another post called ritchters transformation from cll and he’s on their, if you add a comment under his name or msg him directly.

[gsanchez in reply to Hidden]

Thank you!

[Hidden]

gsanchez,

You are asking very technical and complicated questions which likely require a skilled whitecoat to answer. A couple quick points, from my understanding (MBL is considered a precursor to CLL not any type of regression or transformation. In other words, You get MBL first....and for about 2% of those people a year...it turns into CLL.

The fatigue effects many of us...some worse than others, some before treatment, some after....it can come very early, very late, any time in between or not at all. I have it bad and it sucks and I am early stage.

Do you know your chromosome mutation status (11q,T12,13Q or 17p? Or none of the above).

And finally, I would suggest...the reason your husband is in ICU might not be CLL related....don't let the whitecoats just assume it is....it could be...might even be probable...but not everything bad comes from CLL.

Scott

[gsanchez in reply to Hidden]

Thank you! For replying. He is much better everything looks very promising. The next step is to take him out of the respirator. We are taking one step at the time.

[Hidden in reply to gsanchez]

Please let us know everything turns out OK. People care here...a lot

[Cllcanada Top Poster CURE Hero]

Hi Gloria....yes I'm an ex-Richter's patient... sorry to hear this... what a worry!

Are you certain of the terms?

Monoclonal B Lymphocytosis (MBL) is a early stage of CLL, that is not malignant, non-proliferative. I have never heard it in regards to transformation...

Richter's usually transforms to diffuse large B cell lymphoma DLBCL, , in 80% of cases, Hodgkin's Lymphoma or rare PLL. There are a few very very rare types, but I have never run across anyone with any...

~chris

[gsanchez in reply to Cllcanada]

Thank you. The oncologist words were very scary and she was saying that the CLL was being transformed into a more aggressive cancer. Once my husband gets out from the hospital we are going for a second opinion. Right now he is in a respirator but his lungs are functioning properly at this point he is going to satay on just per precaution due to other complications like kidney failure. They suggested diálisis but instead they are going to perform plasmapheresis. He needs to come out of this situation to look for treatment. Really appreciate it.

[gsanchez]

Thank you everyone! My lovely husband passed away on July the 4th due to complications. He developed neumonía that was very resistant to antibiotics and he only stay with us for two days. He fought for 9 years. I wish everyone good luck and stay possible there are better medicine coming your way.

[KL2018]

I’m so sorry to hear the sad news. I hope you have many happy memories to give you comfort. How touching that in your time of sorrow, you reach out and offer encouragement and hope for the future.

[PaulaS Volunteer]

I'm so very sorry to hear that, Gloria. My sincere condolences to you and your family.

Thinking of you...

Paula

[Skyshark]

Gloria hasn't posted on here in 4 years. Sadly from reviewing her replies I found her husband has passed on, on 4th July 2018 due to RS.