The Bottom Line:
In this ongoing trial, the triple combination therapy using acalabrutinib, venetoclax, and obinutuzumab is highly active. Thus far this drug combination has produced durable remissions as a frontline treatment in patients with TP53 mutation CLL and has been generally well tolerated, with a low 2.9% incidence of atrial fibrillation and zero of the more serious abnormal ventricular heart irregularities -
See report at