Israeli research including the Omicron phase "Association between AZD7442 (tixagevimab-cilgavimab) administration and SARS-CoV-2 infection, hospitalization and mortality" on AZD7442 == Evusheld - for immune-compromised - looks promising. Bring on the Evusheld! Personally I'm missing the big conference of the year in my subject partly as a result of government sluggishness on this.
See academic.oup.com/cid/advanc... and note the PDF link.
Good news, thanks for posting.
Hi JIDD,
Fantastic data! Thank you SO much for posting!Israel’s excellent health system allows them to make important contributions in addressing Covid. Given that the U.S. government and commercial companies have little interest in protecting the millions of immunocompromised individuals through the development of antibodies, this data is extremely welcome, important, timely, and IMPRESSIVE.
Maybe someday, antibody protection will overtake Covid vaccines so everyone can be safer.
Best to all!
Yuck
Thanks for posting this JIDD. It's the first clinical study I've seen of Evusheld in the Omicron era, though evidently not the only one.
These encouraging results should be treated with caution - see Discussion in the full text pdf, especially under Study Limitations, where the authors point out several potential sources of selection bias.
Yes it is possible that people who didn't get evusheld had other factors that put them at risk for severe covid.
But the benefits of evusheld were so striking that they can not be explained just by selection bias, for example 40 deaths in the nonevusheld group, zero deaths in the evusheld group.
"Potential selection bias" doesn't invalidate the results. But for reasons identified by the authors, the results may not be quite as strong as you think.
Also, they seem to have pitted Evusheld against Omicron BA1.1 and 1.2 but not against the main subvariants of concern since: BA.4 and more recently BA.5 theconversation.com/how-the...
Thanks for posting!
My view is that in the case of these newer variants Evusheld, like vaccine, is likely to be more useful in reducing the severity of infections than in preventing them altogether. The striking difference in mortality between the two groups may reflect this, though as the authors noted not all the deaths recorded were necessarily from Covid.
I had Evusheld infusion on July 6th, and was overjoyed to get it done. I know that I'll have protection for 6 months, and how grateful I am. The strange thing that boggles my mind is the amount of articles that I have read in the past 2 days that tell how Evusheld is not known by physicians. AZ latest financial report states that Evusheld had dropped in the latest 1/4 compared to the last 1/4. There's lots of boxes sitting on pharmacy shelves just waiting for to expire.
I can’t get the Evusheld shot. I have asked my CLL and regular doctor and they both decline to order it.
I’m in the US.
No problem in getting Evusheld in S Florida. Find new doctors!
Same here. I'm in watch and wait and did produce some antibodies from the vaccine and my doctor said I did not qualify for Evusheld, but he would prescribe it if I wanted him to. I wrote to LLS and they said I absolutely DID qualify. I decided not to argue with my doctor through the patient portal. I will talk to him about it at my appointment next month. I think a lot of Evusheld is going to waste. I looked on some website that said where it was available and it was in stock all over town!
I qualified through UNC hospitals in NC. Recieved it at my local Hemo/onco office (affiliated with UNC) I am watch and wait going on 4 years. I was actually offered it without asking. I asked origionally at Duke onc, and they said I did not qualify at the time. Thats when I switched back to UNC.So check around as different medical groups and hospitals have different qualifiers.
I was fully vaxed, boosted and even had antibodies from the vaccines. UNC did not list having antibodies as a disqualifier.
So persist till you get it.
I can't believe that your CLL doctor would decline you the drug when the Federal government pays for it in full. There's no cost to the population.
I wouldn’t call it sluggishness. The government is doing everything possible to place obstacles in front of purchasing Evusheld. There are Vast amounts of real world data, more than they could ever get in a trial. So many countries already using it and among them is the US with its FDA, which approved it months ago.
Still only 15,813 signatures on "Fund Evusheld the preventative COVID19 antibody for immunocompromised" petition.parliament.uk/peti...
Its now to late to get the issue into the Tory leadership contest so this is our only option. Get signing!
Sadly, there was NO data listed on CLL patients other than only a very small percentage of patients with CLL were included, none of whom were infected.
So the question remains, were the CLL patients not infected because of Evusheld or by random, or by other mechanical prevention measures like masks and distancing.
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