After my second vaccination last year I did a Roche Anti-SARS-CoV-2 Total Antibody Test and it registered 12 U/mL.
The accompanying literature indicates that a reading of less than 0.8 U/mL means negative for antibodies. So something good in my test.
Just received the results from another test which was 3 weeks after my 4th (booster) vaccine. This one indicates 379 U/mL.
Should I be pleased or is that difference between 379 and 2500 still a massive problem?
That's great you have antibodies. They multiply when attacked by virus so your 12 & now over 300 will be a great army!
It's great there has been a good shift in the direction of your antibodies, but as you state it could still be regarded are a lowish result compared to 2500. I don't think anybody knows for sure what is ok, we take risks according to our unique circumstances and personal outlook. I had a very good result for antibodies and t cells, it has changed my behaviour only a little. My close family is allowed in the house if they social distance for the previous days and occasionally I eat out again with my husband. So, in short, my instinct says why not celebrate but proceed with caution 🙂
Better some than none, but they are less effective against Omicron, so don't let your guard down.
I'm not sure that an increase like mine means anything at all, so all my precautions continue. But would be nice if there was any news about research into the possibilities.
Harvist -
I know of a fellow CLL patient who scored in the 700s on the LabCorp spike antibody test. I believe that test was Roche's Elecsys Anti-SARS-CoV-2 S.
She still got Omicron a month or so ago, with terrible headache, muscle aches, and a 102F (39C) fever for several days. But a week later, she was feeling better. She is watch and wait, and has generally normal total IgG, IgM, and IgA. That's just one person, but it's clear that such a score does not indicate full neutralization.
I had no antibodies at all after the first 2 shots, and a measly 4.7U/mL on that same test after the 3rd back in August. I felt really good, though, to see that something was stirring, even if not to the point where I can go to a bar or club while unmasked. I would so like to hear some live jazz and have a beer or cocktail.
I look forward to my results after my 4th shot soon. Just before that shot a couple of weeks ago, my 4.7U/mL had dropped to 2.3U/mL - about 5 months after the 3rd shot. I do plan to try to get Evusheld as soon as I can after the test no matter what the result is. I'm in the Leukemia Lymphoma Society COVID vaccine effectiveness study.
As I read more about immunology, it's not all about the antibodies. T-cells, memory B and T-cells are also stirring. So, the antibody test is a really rough, indirect indication of immune activity. I'm in the U.S., and did a T-cell test from Adaptive Biotechnologies called T-Detect after my first 2 shots:
It came back positive. T-cell testing is in its infancy, and I hope we see more as time goes on. In the U.S. we can order it online, and pay $159 out of pocket. There are a few research papers on it, and it does not return a numeric value - only a qualitative postive vs negative for T-cell activity. I don't think it distinguishes between spike and nucleocapsid. Again, it was nice to see some reaction. I feel a little less vulnerable. In the absence of ability to produce nucleocapsid antibodies, I would like to see a T-cell test that could confirm a past infection.
Adaptive Biotechnologies also has B-cell tests for MRD status for CLL that work similar to the T-Detect test. For B-cells, they do DNA sequencing of the actual B-cell. For T-Detect, they sequence just part of the T-cell receptor. So they do know how to do quantitative testing. Their MRD test is called ClonoSEQ, and may be what the CAR T-cell patients are using to get a much more sensitive MRD status than the usual tests many of us have had.
adaptivebiotech.com/wp-cont...
Alas, they do not appear to be licensed in Europe or the UK yet. There is a T-Cell test using different technology in the UK, though:
privateharleystreetclinic.c...
=seymour=
Covid 19 Vaccine antibody results
Vaccine Antibody Test Results 
Vaccine and Evulsheld
