My post on getting a third shot on my own, without approval from the government, has had very wide readership on this site. It should be so, because it is perhaps one of the bigger concerns we all should have right now.
Now the good news is that the government here in the US is about to approve a third shot for the immunocompromised; namely, us. Here is the story from the NY Times
F.D.A. to Authorize Third Vaccine Dose for People With Weak Immune Systems
The decision to expand the emergency use of both the Pfizer-BioNTech and Moderna vaccines is meant to help transplant recipients and others whose immune systems are similarly compromised.
By Sharon LaFraniere and Noah Weiland
Aug. 11, 2021
WASHINGTON — Federal regulators are expected to authorize a third shot of coronavirus vaccine as soon as Thursday for certain people with weakened immune systems, an effort to better protect them as the highly contagious Delta variant sweeps the nation.
The decision to expand the emergency use of both the Pfizer-BioNTech and Moderna vaccines is meant to help those patients with immune deficiencies who are considered most likely to benefit from an additional shot. It covers people who have had solid organ transplants and others whose immune systems are similarly compromised, according to an official familiar with the plan.
The development will give physicians latitude to recommend additional shots for those patients. About 3 percent of Americans have weakened immune systems for a variety of reasons, from a history of cancer to the use of certain medications such as steroids.
Many scientists argue that the immunocompromised population is too diverse to uniformly recommend additional shots of coronavirus vaccine. Some may be protected by the standard vaccine dosage, despite their conditions. Others may be poorly shielded by the vaccines, but unable to benefit from an additional shot.
Studies suggest that patients such as organ transplant recipients are in between — often showing little immune response to the standard vaccine regimen, but benefiting from a third shot. One recent randomized, placebo-controlled study by Canadian researchers found that a third dose of the Moderna vaccine improved the immune response of people in that group.
Dr. Dorry Segev, at the Bloomberg School of Public Health at Johns Hopkins University, has said about half of transplant patients have no antibody response to the currently authorized vaccine dosage. His team studied 30 transplant patients who were vaccinated but had negative or low-positive antibody titers, which suggested a poor response by their immune systems to the shots. After an additional shot, 14 of them had higher antibody titers.
The Food and Drug Administration’s decision to authorize a third shot for organ transplant recipients and those with similarly compromised immune systems will be considered by an advisory committee to the Centers for Disease Control and Prevention, scheduled to meet on Friday. Although the F.D.A.’s action is independent of the panel’s recommendation, in practice many physicians wait to act until the C.D.C. weighs in.
If the committee votes to endorse the shots, as expected, the C.D.C. could issue a recommendation the same day. That could give further guidance to physicians and pharmacists about how to proceed.
France has offered additional vaccine doses to certain people with poor immune responses since April, and Germany and Hungary recently followed suit. After considering several regulatory pathways, health officials in the Biden administration decided that expanding the emergency use authorizations for Pfizer and Moderna was the fastest route to reach those most in need. The F.D.A. is also expected to grant full approval to Pfizer-BioNTech’s vaccine by early next month, a move that also would give physicians more freedom to prescribe additional doses.
Although the vast majority of Americans who have been vaccinated received Pfizer or Moderna shots, it was not immediately clear how those with immune deficiencies who received Johnson & Johnson shots were to proceed.
The F.D.A. decided not to broaden emergency use of the single-dose vaccine, at least in part because health officials wanted to see Johnson & Johnson’s clinical trial data on the safety and efficacy of two doses first, according to one official. Johnson & Johnson is expected to release the results of its two-dose study this month.
Some Biden administration officials are debating whether vulnerable segments of the general population will need booster shots to shore up their protection against Covid-19 — a decision that a number of scientists and public experts argue cannot be justified by current data.
Any such strategy would be based on a different risk-benefit calculus because the vaccines have proven extremely effective against severe disease or hospitalization for those without immune deficiencies. Some ordinary citizens are already seeking booster shots on their own, without waiting for an F.D.A. decision or a C.D.C. recommendation.
Dr. Dan Barouch, a virologist at Beth Israel Deaconess Medical Center in Boston who worked with Johnson & Johnson as it developed its vaccine, said the F.D.A.’s move to make third shots available to some with weakened immune systems made sense. But he said a similar approach could be attractive to physicians and patients: getting a different kind of vaccine altogether.
Dr. Barouch said there was a long and successful history of mixing and matching different vaccine platforms for other viruses. Because of the similarities in how coronavirus vaccines were produced, he said, mixing was particularly appealing, since it could potentially boost and broaden one’s immunity.
There is no data yet to determine whether protection against the virus is enhanced by such an approach, Dr. Barouch said. But researchers at the National Institutes of Health have a study
underway that is expected to deliver some answers by early fall.
Sharon LaFraniere is an investigative reporter. She was part of a team that won a Pulitzer Prize in 2018 for national reporting on Donald Trump’s connections with Russia. @SharonLNYT
Noah Weiland is a reporter in the Washington bureau, covering health care. He was raised in East Lansing, Mich., and graduated from the University of Chicago. @noahweiland
Carl
What about a 3rd vaccine shot (booster) for CLL patients?
3rd Covid shot while still receiving (O & V)?
UK: Here’s a list of people who are eligible for the 3rd dose of Covid vaccine. 
