My husband has had CLL for over five years now, and was on Wait and Watch for 2 years before everything went really bad: fatigue,fevers, 160,000 white blood count and multiplying faster and faster, terrible infections. He started out with a chemo therapy: BR and that crashed all systems. He only had 4 infusions and then they said no more! He had zero neutrophils and was severely neutropenic for nearly 6 months. He has been on Ibrutinib for a year now, and after a CT scan last week and lab work today, his doctor said he was in REMISSION!! All labs were in the normal range, and his lymph nodes in his neck, stomach and lower abdomen had returned to a normal size. Praise God and thanks to all the prayer warriors out there. I know he is not cured, but we just got back from an Alaskan cruise and this was the best news ever! Take heart everyone!