I found many valuable information and discussion on effects of EGCG, surprised to hear that a large amount of EGCG uptake may have a risk of DNA damage, because I did not know it.
I am taking 2g EGCG/day (1g in the morning, and 1g in the afternoon), so I am afraid that chromosomal aberration occur in the CLL cells to evolve toward aggressive clone. I have read several articles on the effects of EGCG on cultured cell chromosomes. I summarized my understanding obtained from papers.
(1)Hydrogen peroxide (a kind of active oxygen) generates due to EGCG, and it is related with chromosomal aberration.
(2)When EGCG greater than 100 micromolar/L is added to culture medium, chromosomal aberration occurs in cultured cells. However, hydrogen peroxide is not detected and chromosomal aberration does not occur in the presence of 10 micromolar/L EGCG.
(3)Below 1 micromolar/L EGCG, chromosomal aberration induced by another drug (or active oxygen?) seems to be suppressed.
(4)When 1g EGCG is taken, plasma EGCG concentration reach in 4 hr, and the concentration is 1 micromolar/L. Thereafter, the plasma EGCG concentration decrease in several hours.
(5)In general, the cancer cells may not contain catalase, so they are sensitive to hydrogen peroxide. In some paper, it is described that the CLL cells have enough catalase which is scavenger of hydrogen peroxide. I expect that hydrogen peroxide may be destroyed by catalase if small amount of hydrogen peroxide is produced by 1 micromolar/L EGCG.
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J. Nutrition 132: 1836-1839 (2002)（ jn.nutrition.org/content/13... ）
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