My CLL is characterized by IGVH unmutated, deletion 11q, deletion 13q, and CD38 positive. There is no question that I fall into the high risk CLL bucket. But am I also a complex karyotype? My understanding is that the definition of complex karyotype is 3 or more CLL cell mutations. I know I have 2 (deletions of 11q and 13 q), but I'm not certain if CD38 positive is also considered a cell mutation. My reason for caring is that I have read that a complex karyotype increases the likelihood of ibrutinib resistance. I'm currently in remission, but am always interested in what future treatments my be effective for me
Help from the experts on this is appreciated.