I have had high liver function test results for the past year and a half, fluctuating between twice and five times the upper normal limit. Initially it was the GGT that was high. Then the ALT, then the ASP and now the AST as well. Plus my urea is v low. I have done all the possible imaging tests and had a liver biopsy too. The biopsy showed slightly fatty liver but the hepatologist does not believe that it is the cause of such high levels. All the imaging tests show smooth, normal liver, no gall stones. The gallbladder is slightly "lazy" but the tests did not conclusively show that it isn't functioning. I have no outward signs of liver disease.
The hepatologist believes that it is a sphincter of Oddi disorder (making the bile backing up in the liver, thereby increasing the function levels). To get a clear diagnosis for that I need to have a specific endoscopic procedure to measure the pressure of that sphincter but as I have not much pain, nor visible signs, and taking into account that the procedure carries the risk of pancreatitis, I'm reluctant to have it.
I'm also a lupus sufferer but the biopsy etc confirmed that it isn't the one affecting the liver. The antibodies related to liver are negative. PBC has been ruled out, hepatitis has been rippled out (including the autoimmune).
Still, I'm worried about these high results. I have been on a very strict diet for the past 6 months to control the lupus, no alcohol either. I expected the results to improve but they haven't. My hepatologist says that that is the nature of disorders of the sphincter of Oddi but I'm worried that it is liver disease that is not being picked up.
Has anyone had such high results (up to 5 times over the normal upper limit) without having any visible signs of liver disease? If so, what was your diagnosis?