I will be much thankful if you could help me with your advice..my wife CA breast patient underwent treatment 2 years ago and was on tamoxifen 20 mg. She had surgery chemo and radiation. Now past two weeks experiencing severe head ache. The MRI showed enhancement of meninges. Csf cytology found mildly atypical cells. The doctors have suggested for repeat of LP. I understand they are suspicious of metastasis. How risky is it? are there effective chemos for this state ?