use of cuyproterone for reducing hot flashes

[Leigh2350]

2 years ago I started on 3 monthly injections of goserellin which has taken psa level to undetected.

Have recently added Abiraterone ( Yonsa ) 500 mg per day and hot flashes have re-emerged as a major issue. MO won’t prescribe Estradiol and has instead proposed cuyproterone.

Tall Allen, do you have any comments on this.

Many thanks

[Tall_Allen]

Yes, it should help while providing ADT. I don't usually recommend it because it's not available in the US.

[Leigh2350 in reply to Tall_Allen]

Many thanks.

[kainasar in reply to Tall_Allen]

Found this on IndiaMart m.indiamart.com/isearch.php...

[janebob99]

Did your doctor say why he/she wouldn't prescribe estradiol?

You may want to ask your PCP or GP to prescribe it, instead, to relieve you of the symptoms of ADT. That only being humane. That's what I did. If you need a good paper to give to your physician(s) send me request to [e-mail].

[Aardvark4]

Why, if your PSA has been undetectable for over two years, has the decision been made to start Abiraterone. A rise in Testosterone maybe?

[Leigh2350 in reply to Aardvark4]

It was nothing to do with Testosterone.

The Stampede trial shows that the addition of Abiraterone to Goserelin significantly improves my overall survival. Ideally, I should have been having both drugs from day one of diagnosis as MCSPC, but in New Zealand Aberiterone is only funded when you become CR. The cheaper generic version called Yonsa only became available here three weeks ago. I am paying for this personally.

[Aardvark4 in reply to Leigh2350]

how much prednisone are you taking, it should be 2.5mg

[Leigh2350 in reply to Aardvark4]

Yonsa is prescribed as 500 mg daily plus 4mg of prednisolone for CS patients like myself, or 500 mg plus 8 mg of prednisolone for CR. I have not found an explanation for the different doses.

[Aardvark4 in reply to Leigh2350]

I believe it's 500mg Abiraterone/2.5mg prednisone once a day for CS patients; wonder why a generic version would be different

[Aardvark4 in reply to Aardvark4]

ah, probably because your metastatic CS

[j-o-h-n]

Sic your sheep on your M.O.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Camdude]

Hi Leigh,

I have been on Cyproterone for the last 6 months for hot flushes. I have the three monthly Ellegard injection and Nubeqa tablets every day.

The Cyproterone have certainly helped with hot flushes. From my research this was an early form of testosterone blocker but has been replaced by drugs like Nubeqa etc because of less side effects.

I ended out reducing the amount I was taking as my oncologist said there are no studies to show side effects of being on three hormone blockers. I have been taking half a 50 mg tablet morning and evening. Originally I was on 50 mgg three times a day.

Wikipedia has an excellent article on Cyproterone acetate. It does have potential serious side effects and therefore the lower the dosage the better.

I have decided to come off Cyproterone and see whether the hot flushes are still a problem. Having said that I was so grateful to find something that helped as the hot flushes were wrecking my sleep.

Hope that is helpful,

cheers,

Camdood

[Leigh2350 in reply to Camdude]

Thanks for your comments. I was a bit cautious about Cyproterone having read about out it, so started on 25 mg daily. By day 3 my BP was 170 /92 compared to my recent average of 148/82 so have discontinued. It reduced my hot flushes partly, but not enough to warrant the jump in BP.