Psa is on a steady increase again. I was taking extandi for a year up until 11 /23 over that yr my Psa had dropped from 29, 11/22 to 1.4 ,11/23. I was having significant SEs, brain fog mainly so I decided to switch to nubeqa (daralutimide) even tho there was a steady drop in PSA on extandi. Nubeqa was a breath of fresh air but now it appears i made a mistake to switch. after 3 months on nubeqa psa increased to 2.6on 2/24 and now5.6, on 5/24. I have also been on orgovix for 1.5 yrs now.
So .. My first thought was to go back to extandi because it was working and try to deal with the SEs.? Do you think there is a possibility of it working again? Another choice would be docetaxel. I understand that with increasing PSA the docetaxel may be effective. I have never used any chemo drugs. Looking for some wisdom from the clan here as i read every post daily and there is a world of knowledge here.
I have an appointment with my MO next week so I need ideas to plan a course. I appreciate all of you!
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rick8637
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probably you know Xtandi and Nubeqa are from same class means MO may tell you if you fail Nubeqa means Xtandi will not work because cancer is hormone resistant.
Overcome from hormone resistant mostly MO suggest chemo. I think it is right way as well.
Please ask following questions. there is research out there combinations of Niclosamide and Bicalutamide help to overcome from hormone resistant of Xtandi or similar drug. Here is
IDK why you care particularly about AR splice variants, and why anyone would use unproven and toxic (at least in current formulations) drugs like niclosamide. I can't see why you would offer such possibly unsafe and ineffective advice without clinical data.
Knowing that 99% of lab studies show no effect in clinical trials, and there may be toxicity that lowers survival, how does it help to know what works in mice?
Combine current nubeqa with docetaxel? Is that what you mean? Or nubeqa with extandi? I have trouble reading these test results.. I have no Aphinity for deciphering this data .. ignorance is me
my husband did taxotere first, then zytega, later Xtandi. He returned to taxotere after zytega & xtandi quit working. He lost his hair, does have neuropathy but weathered the treatments well. I would recommend a port if doing chemo. My husband started his treatments in 2017 with surgery/radiation. He was 64. Now at 71 he is doing Jevtana chemo
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My trajectory after a "vacation" and a new metastasis
Time for a vacation, but worried about IADT
Cyclic high dose testosterone + Nubeqa
Time for Pluvicto? 
Rising PSA 
