Radiation PSA, Orgovyx, Bone density Update 2/18/24

[alperk]

Rouge clone radiation on 10/31/23 has PSA from 4.83 on 11/20/23 to 0.85 on 12/18. HOWEVER, PSA up to 1.48 on 1/29/24 then 2.48 on 2/15/24.

Waiting MO response but anticipate PET scan, radiation and/or switch to Xtandi. Was hoping to ride the Zytiga therapy as long as possible but I may be there now.

[maley2711]

what is rogue clone radiation????

[alperk in reply to maley2711]

My MO says "You are describing is what we call oligo progression and the few lesions that might show growth may be what I call Rogue clones and usually what I do is not stop or change the current treatment and just add stereotactic radiation to the areas that showed progression usually 3 lesions or less."

From Goggle:

Oligoprogression is an emerging concept in oncology, denoting a state where after an initially successfully systemic therapy of disseminated metastases, a single/few lesions display further progression.

[maley2711 in reply to alperk]

Ok, just never seen that terminology before!! A number of studies confirm benefit for some men for RT when oligometastatic. GOOD LUCK !!!!!!!!!!!!!!!!!!!!!!!!

[jbskiatook]

Xtandi is not that bad as soon as you learn now to contend with side effects. Highly recommend getting on a good diet and exercise program. Seems biggest side effect is weight control and just getting lazy.

[alperk in reply to jbskiatook]

I have been on Zytiga since 8/21. It has been doing it's job in keeping my numerous bone mets at bay with only 2 lesion growth incidents - Oligoprogression. I believe Xtandi, like Zytiga has a useful time limit so I want to delay it's start as long as possible. Seeking comments on treatment plans.

[jbskiatook in reply to alperk]

Yes That is in the back of my mind also but not doing much yet. You may be interest in a free virtual group that has very informed members and 3 doctors who you can get ideas from. Very nice bunch. What I attend is the High Risk/Recurrent/Advanced Prostate Cancer weekly meeting. The web site is ancan.org/prostate-cancer/

[j-o-h-n]

Well, Well another War Baby....... remember "save your fat in cans"..... Keep fighting and Winning....as we did in the big one........

Good Luck, Good Health and Good Humor.

j-o-h-n

[CAMPSOUPS in reply to j-o-h-n]

My nana's food was great. Thanks in large part to that "can" next to the stove.

[j-o-h-n in reply to CAMPSOUPS]

Makes good light brown bathtub lye soap too........your Nana, my Yiayia.....

Good Luck, Good Health and Good Humor.

j-o-h-n