Moving on to Provenge/Sipuleucel-t

[Lavender22]

We met with my husband's onc yesterday to discuss the next move since the 3 years of Abiraraterone/prednisone has run its course. His psa numbers are now around 2.0 (up from a low of .04) and psma scan indicates that bone met volume is quite low. A recent lab biopsy didn't reveal much...

The good doc said he's a good candidate for immunotherapy at this stage; the point is to boost and tailor his immune system to help fight the cancer and also will retain a decent QOL. So Provenge infusions will begin in a few week's time. It sounds like this will likely be followed by Lu-177 down the road, or perhaps another round of chemo.

I've read various previous posts on the subject here and they are quite helpful.

We'll keep you posted.

E

[God_Loves_Me]

I think having PSMA PET scan can tell you more.. if your husband has less than 5 mets, you can also include SBRT Radiations treatment with provenge. I think SBRT radiations + Provenge has great results

[Lavender22 in reply to God_Loves_Me]

Yes, he had the psma scan quite recently ( I need to update the bio info.) quite recently- showed 3 low volume lesions, one of which was biopsies, as mentioned.

Onc. said that if/when he felt pain they could do the SBRT radiation.

At the onset of this cancer he did have SBRT and then chemo. This was before SOC was triplet therapy. So the Abiraterone/Lupron/Prednisone/Exgeva followed.

Thanks for your information.

E

[Tall_Allen]

Combining it with a therapy that kills prostate cancer cells directly may augment its usefulness. This includes Xofigo and chemo. The idea is the dead cancer cells are in the bloodstream where they present cancer antigens to the dendritic cells.

ncbi.nlm.nih.gov/pmc/articl...

The synergy with chemo is that Provenge amps up the immune system that is depressed by chemo.

[Lavender22 in reply to Tall_Allen]

Thanks, TA. I will read this.

Onc did say Carbataxol or Lu-177 likely to follow. I’ll find out if she meant concurrent after the sets of infusions (3).

Xfigo lower on her to do list.

E

[EdBar]

I recommend that he opts for a port when receiving Provenge, I didn’t and wish I had, it makes the treatment much easier. Less sticks with big needles, and you can use your hands while going through the tedious task of Plasmapheresis.

Ed

[dhccpa in reply to EdBar]

Didn't realize you had done Provenge. Still unclear on exactly when it is used. Anytime after castrate resistance? Can be combined with any other treatment like chemo, Pluvicto, etc?

Thanks

[EdBar in reply to dhccpa]

It is most effective when PSA is <5, since chemo is going to ravage your white blood cells it’s probably not a good idea since they need to collect them for the treatment. For me Pluvicto is one of the bullets I’m holding back on, there’s not too many treatments left beyond that. You can read my profile to see what I’ve done for treatment.

Ed

[dhccpa in reply to EdBar]

Thank you. Yes, I just re-read it. Good info and detailed and clear.

[Lavender22]

Thanks EdBar,

I have shared this information with my husband. It makes sense.

E

[j-o-h-n]

May it all work for him........

Good Luck, Good Health and Good Humor.

j-o-h-n

[Lavender22]

thank you, John.