All cases of prostate cancer exhibit the hallmark condition of marked decrease in zinc in malignancy compared to the high zinc levels in the normal and benign prostate. There exists no reported corroborated case of prostate cancer in which malignancy exhibits the high zinc levels that exist in the normal prostate acinar epithelium. The decrease in zinc is achieved by the downregulation of ZIP1 zinc transporter, which prevents the uptake and accumulation of cytotoxic zinc levels. Thus, prostate cancer is a “ZIP1-deficient” malignancy. Testosterone and prolactin are the major hormones that similarly regulate the growth, proliferation, metabolism, and functional activities of the acinar epithelial cells in the peripheral zone (the site of development and progression of malignancy). Testosterone regulation provides the basis for androgen ablation treatment of advanced prostate cancer, which leads to the development of terminal androgen-independent malignancy. Androgen- independent malignancy progresses under the influence of prolactin. These relationships provide the basis for the prevention and treatment of advanced prostate cancer. Clioquinol (zinc ionophore; 5-chloro-7-iodoquinolin-8-ol) is employed to facilitate zinc transport and accumulation in the ZIP1-deficient malignant cells and induce cytotoxic effects. Cabergoline (dopamine agonist) is employed to decrease prolactin production and its role in the progression of androgen-independent malignancy. We propose a clioquinol/cabergoline treatment regimen that will be efficacious for aborting terminal advanced prostate cancer. FDA policies permit this treatment regimen to be employed for these patients.
supplement with zinc for testosterone cancer, supplement with Cabergoline for prolactin cancer. Chances are your doc is only treating for testosterone cancer.
ncbi.nlm.nih.gov/pmc/articl... - that is about zinc supplementation, we passed here “the risk” and in case of androgen independent stage maybe potential reward outweighs the risk….
First of all, ask your MO to measure prolactin level. Secondly, zinc in moderation (I currently take 15 mg of zinc sulfate, natural liquid, nano-ionic minerals professional grade; each bottle 128 servings.) Thirdly, I wouldn't mess around with drugs that have affects systemic (other than prolactin, dopamine) with a host of possible side effects:
What side effects may I notice from receiving this medication?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
chest pain
confusion
hallucinations
new or increased gambling urges, sexual urges, uncontrollable spending, binge or compulsive eating, or other urges
persistent cough
swelling of the ankles, feet, hands
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):constipation
The nutritional supplements Mucuna Pruriens (95% L-Dopa) and Vitex Agnus-Castus (0.5% agnusides) have shown some evidence that they decrease prolactin in males. Could be worth a try to see if that has a positive effect on one's resistant PCa (reduction in PSA or shrinkage on scans), and only then pursuing the riskier cabergoline or bromo by Rx with your onco or GP.
Clioquinol 3/ day+ 50 mg zinc /day Cabergoline/day. No ADT or CRPC. Internal the prostate pushed the urethra against the perineum which raised a ridge on the outside.. I applied the Clio three times/day along side the ridge for three days and on the fourth day the ridge was gone. The prostate had shrunk. I'll take PSA and prolactin count in Oct.
Sept 1, right nipple became very sensitive and a 2" harndess formed around it. Today the hardness shrunk to the size of a dime. Clio + zinc KILLS cancer.
My good results are from less than a months treatment with Clio. I don't know what the results would\d be if the prostate had been removed. My guess would be if there were cancer cells present that Clio would kill them unless they were prolactin dependent then the Cabergoline would starve them.
CT scan showed no spread, bone scan showed possible lymph involvement. I will report after scans when I take them. Results are based on observation that my perineum is no longer hardened and that the 2" diameter hardness on my breast is the size of a dime. U of Maryland says Clio + zinc kills cancer cells and my observation is that they are right. Time will tell.
After reading your bio my thought is that when all else has failed what have you got to lose by trying Clio +zinc. Two oz's of Clio cost me $125 and its lasted almost two months.
Will be great if you keep us updated in a few months with your blood tests and scans to see that it is actually sustainable for a certain period of time.
If someone ban you from this forum, it could happen… then you can register at Fight Prostate Cancer in HealthUnlocked as well, there is less chances to be banned.
LOL - well not quite as simple as agnate describes but also back then people were taking it orally I think. It is available in the US as a topical ointment in the US which is what the experiment used.
While versatile and used worldwide, clioquinol became associated with a mysterious illness primarily confined to Japan. Between 1958–1970, Japanese physicians observed a number of cases that, at first, were characterized by mild abdominal pain and/or diarrhea (Kono, 1971). These symptoms were often followed by a myelitis-like illness that exhibited an array of neuropathological changes consisting of “pseudosystemic degeneration involving the peripheral nerves, post-lateral columns of the spinal cord and retrobulbar optic nerves” . The new illness was designated as subacute myelo-optic neuropathy or SMON, with unknown etiology. It affected thousands of people who were blinded, paralyzed or confined to wheelchairs for the rest of their lives. 10,000 diagnoses were made and nearly 5 % of cases were fatal . Multiple hypotheses on the etiology of SMON were considered: intoxication by industrial waste or pesticides; a metabolic disorder or vitamin deficiency, and involvement of viral or bacterial infections (Kono, 1971), none of which were confirmed by subsequent studies. SMON patients presented with a green “fur” on their tongues, and green-pigmented urine and feces. Surprisingly, this green pigment was identified as the Fe (III) chelate of clioquinol . Moreover, the number of SMON monthly cases closely correlated with the number of clioquinol tablets consumed, and only patients that took clioquinol exhibited symptoms of the disease (Kono, 1971). This necessitated a ban of clioquinol sales in September 1970. As a result, the monthly SMON incidence went from ~ 150 in July to 1 in October. However, one mystery that remained was that SMON was primarily endemic to Japan. Internationally, the 1969 sales of clioquinol per capita in 15 studied countries were higher than in Japan, yet there were no reports of SMON . Some researchers speculated that familial (genetic) factors could account for the higher incidence of SMON in Japanese clioquinol users (Kono, 1971).
Thank you for your very thorough reply. There are so many side effects from Clioquinol, I think I will avoid it. Doctor wants to put me on Firmagon which can be terrible (Incite.com, Firmagon). I am pushing for Orgovyx but Dr. claims will not be absorbed because I am on dialysis. But he is wrong. May have to change doctors. Again, thank you.
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Zinc. Yes, Costello & Franklin again.
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