Very interesting and important. Hormone therapy failure prevented or reversed

[Sxrxrnr1]

Offered without comment,

Thoughts and opinions?

mathewsopenaccess.com/schol...

[pjoshea13]

I agree.

But the study has already prompted two threads on Cabergoline & prolactin that are worth visiting.

-Patrick

[NPfisherman]

George71 and tango65 posted on this a week or so ago...it is an option I have put in the case files to pull out at a much later date, God willing, and worth a shot.......Reading Friedman and early in his book, he blames PCa on Estrogen and ER alpha...

Thanks for posting....

Don Pescado

[Sxrxrnr1 in reply to NPfisherman]

Thank you, I missed the postings. Can you give posting links so as I can see what those in the know responded

[NPfisherman in reply to Sxrxrnr1]

Doing your legwork...LOL...use the "Search HealthUnlocked" on the right in the future--

healthunlocked.com/advanced...

healthunlocked.com/advanced....

healthunlocked.com/advanced...

healthunlocked.com/advanced...

How's that??

Don Pescado

[Tall_Allen]

Prolactin inhibitors have been ineffective in early clinical trials and have been abandoned as far as I know.

"No antitumor activity was detected."

ncbi.nlm.nih.gov/pmc/articl...

[NPfisherman in reply to Tall_Allen]

I do not think they are done looking at Prolactin in regards to MCRPC--see beow:

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/312...

jpet.aspetjournals.org/cont...

Also. LFA 102 is an anti-prolactin receptor antibody as opposed to Cabergoline which is a Prolactin Dopamine Agonist....

It is not a done deal yet, and I guess we shall have to wait and see as Science moves forward....

Don Pescado

[Tall_Allen in reply to NPfisherman]

I can't find any clinical trials for it. Cabergoline mildly inhibits prolactin; LFA 102 is a powerful prolactin-receptor blocker - If LFA 102 doesn't benefit PC, why would cabergoline? A single case study doesn't outrank a clinical trial among 73 men. I doubt there will be much interest. But we shall see.

[cesanon]

Just have to love this forum for these kinds of discussion. You just can't find it anywhere else.

[Sxrxrnr1 in reply to cesanon]

I suspect many discussed topics found on this forum and the information gleaned from actual victims of this disease, provides food for thought to many medical professionals that likely participate in this forum, that perhaps they should be looking to the right for answers instead of to the left where they are not finding what the seek.

There is a tremendous amount of expertise stored in the intellect and consolidation of knowledge from actual patients that can and likely is tapped by some researchers.

I have often been amazed by introducing to my MO’s Information that I have discovered thru my own research, to find my MO’s and other PCa specialists that they had not a clue what I was talking about.

An example a year ago, among several I might add,,,,was asking an MO to prescribe a AR-V7 test to determine if I might be negative or positive when he and I were considering Zytiga after having failed Xtandi. He had never heard of it and when I first brought it up and he skeptically queried me on it, I had to tell him that I had not learned of it from the National Enquirer website.

I suspect many on this site can report similar incidents.

[Nachas613 in reply to Sxrxrnr1]

So did you get the arv7 test?

[Sxrxrnr1 in reply to Nachas613]

Yes I did have the test. Result was a negative finding which is good(kind of). A positive reading is definitely bad.

[j-o-h-n in reply to cesanon]

As per your request: "stop reading my posts please. Thanks" I did not read your post.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/10/2019 10:08 PM DST

[cesanon]

"many medical professionals that likely participate in this forum"

I don't think we have many, if any, medical professionals here. But we have at least one poster here, whose judgement I would trust more than most on the subject of diagnosis and treatment of prostate cancer. And a fairly decent team of back benchers.

And the team seems to be slowly growing in strength.

Ustoo has a nice forum. A larger forum. But it just doesn't match this one in quality.

[6357axbz in reply to cesanon]

I agree. The one oncologist I mentioned that a blog was the source of some information I wanted to discuss with him shook his head and sneered “blogs!”

[cesanon in reply to 6357axbz]

It's hard to blame him. And there is a fair amount of snake oil here.

But there is a lot of good stuff here as well.

[Sxrxrnr1 in reply to cesanon]

There’s an old adage suggesting the rareness of intellect and skepticism to have the innate ability in being able to pick the flyspecks out of the pepper.

I paraphrased a bit.

[j-o-h-n in reply to cesanon]

As per your request: "stop reading my posts please. Thanks" I did not read your post.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/10/2019 10:08 PM DST

[j-o-h-n in reply to cesanon]

As per your request: "stop reading my posts please. Thanks" I did not read your post.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/10/2019 10:08 PM DST