A New Year, What Developments are you Hopeful About?

So I am still new, and there is literally a blizzard of new terms i am trying to get my head around. For the guys that have been at this a while, whats on the horizon that gives you hope and why?

For me this paper that shows the reduction of prolactin seems to have an effect on castrate resistant PCa. This was posted by 45yrsDenmark about a week ago.

ncbi.nlm.nih.gov/pmc/articl...

"Those patients with androgen-independent prostate cancer can now employ this cabergoline treatment to prevent or terminate this deadly type of prostate cancer."

Not too many weasel words in that sentence!

[LearnAll]

I read many research articles about prolactin and its role in castrate resistant prostate cancer. This seems like a fascinating area to look at

Yesterday, I got my serum prolactin level which came 9.5 ng/ml (range 2-18 ng/ml)

I am still castration sensitive so I am not sure if I should try to lower it further at this time or wait until I become casration resistant. Keeping an eye on more studies about it.

[Hidden]

I'm hoping to see more progress in targeted treatments for variants and also PSMA-based targeted radioisotopes.

Hoping for approval of LU-177-PSMA 617 as well as advancements in other targeted radioisotopes.

[LearnAll in reply to Hidden]

My dream is that we finally have a metabolic treatment to this metabolic disease.

Upgrades of chemo, radiation or surgery kills lot of cells but keeps some alive so the patient keep rotating thru these shamelessly expensive treatments which do not cure,

Imagine having metabolic pathway blocking medicines who kill the entire population of cancer cells causing real cure and liberation from this disease.

What will happen to these billion dollar businesses who deliver treatments which do not cure and keep the patients as repeat customers forever.

Once such molecular, metabolic curative treatments come to market, the onco industrial complex will collapse and patients and families will have sigh of relief.

[TFBUNDY in reply to LearnAll]

I'm with you all the way. Cheers

[tallguy2]

I want to see precise treatments for each person based on the genetic makeup of his prostate cancer. Instead of "throwing the kitchen sink" at every cell with chemo we may see in this new decade a treatment tailored for each person.

I have asked my urologic MO for an opinion of this one-off prolactin study. It may take my face-to-face meeting in 4 weeks to get an answer.

[Hidden]

A truly revolutionary game changer.

ai.googleblog.com/2019/12/d...

[Magnus1964]

Darolutamide and Proxalutamide are new advances. but the FDA needs to made these drugs available to Pca patients regardless of mets or no mets, castrate resistant or not.

[bwochf]

I'm very interested in the study results (published in Medicalexpress / Dec. 4. 2019) of the Duke University med. Center:

New, non hormonal target identified for advanced PC.

Is science coming?

[Hidden in reply to bwochf]

Here it is

m.medicalxpress.com/news/20...

[Hotrod65]

Genomic Sequencing to determine ones DNA Mutational load and match it to an effective treatment with precision targeted therapies, very individual and personalized.