Has anybody been prescribed Clioquinol - Advanced Prostate...

Advanced Prostate Cancer
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Has anybody been prescribed Clioquinol

hersheyboy
hersheyboy

Just read this inspiring article

“Review Article Open Access

Evidence that Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore (Clioquinol) Approach”

39 Replies
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Here is the link to the full text:

ncbi.nlm.nih.gov/pmc/articl...

I had a Clioquinol post 3 years ago which may be of interest:

healthunlocked.com/advanced...

& it came up again 2 years ago:

healthunlocked.com/advanced...

-Patrick

Nalakrats
Nalakrats in reply to pjoshea13

Do you know what the molecule looks like. Or the Molecular Formula?

Nalakrats

hersheyboy
hersheyboy in reply to Nalakrats

C9H5ClINO

Nalakrats
Nalakrats in reply to hersheyboy

I got the double ring structure---> another drug we can add to the pile that is literally piling up, or re-used old drugs that are anti-virals, to go with the Cholera, Malaria, Tapeworm, Pin worm, ringworm and a pesticide and insecticide drug.

Seems the actions are the same, by interfering with messages the Pca cells get to consume glucose, or to divide. This interference seems to occur, by the breaking of the mRNA strands, which is suppose to send the messages.

Nalakrats

j-o-h-n
j-o-h-n in reply to Nalakrats

Keep away from Roundup... Weed is oops Weeds are beautiful. Sending some to my ex-wife for Valentines day.

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 02/12/2019 7:05 PM EST

Myriammole
Myriammole in reply to pjoshea13

How are you doing to get zinc to the tutor cells? are you taking clioquinol or any other approach?

pjoshea13
pjoshea13 in reply to Myriammole

I use zinc citrate (50 mg) on the basis of this study:

ncbi.nlm.nih.gov/pubmed/183...

Carcinogenesis. 2008 Sep;29(9):1692-700. doi: 10.1093/carcin/bgn027. Epub 2008 Feb 28.

Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells.

Dubi N1, Gheber L, Fishman D, Sekler I, Hershfinkel M.

Author information

Abstract

Prostate Zn(2+) concentrations are among the highest in the body, and a marked decrease in the level of this ion is observed in prostate cancer. Extracellular Zn(2+) is known to regulate cell survival and proliferation in numerous tissues. In spite of this, a signaling role for extracellular Zn(2+) in prostate cancer has not been established. In the present study, we demonstrate that prostate metastatic cells are impermeable to Zn(2+), but extracellular Zn(2+) triggers a metabotropic Ca(2+) rise that is also apparent in the presence of citrate. Employing fluorescent imaging, we measured this activity in androgen-insensitive metastatic human cell lines, PC-3 and DU-145, and in mouse prostate tumor TRAMP-1 cells but not in androgen-sensitive LNCaP cells. The Ca(2+) response was inhibited by Galphaq and phospholipase C (PLC) inhibitors as well as by intracellular Ca(2+) store depletion, indicating that it is mediated by a Gq-coupled receptor that activates the inositol phosphate (IP(3)) pathway consistent with the previously identified zinc-sensing receptor (ZnR). Zn(2+)-dependent extracellular signal-regulated kinase and AKT activation, as well as enhanced Zn(2+)-dependent cell growth and survival, were observed in PC-3 cells that exhibit ZnR activity, but not in a ZnR activity-deficient PC-3 subline. Interestingly, application of Zn(2+)-citrate (Zn(2+)Cit), at physiological concentrations, was followed by a profound functional desensitization of extracellular Zn(2+)-dependent signaling and attenuation of Zn(2+)-dependent cell growth. Our results indicate that extracellular Zn(2+) and Zn(2+)Cit, by triggering or desensitizing ZnR activity, distinctly regulate prostate cancer cell growth. Thus, therapeutic strategies based either on Zn(2+) chelation or administration of Zn(2+)Cit may be effective in attenuating prostate tumor growth.

PMID: 18310092 DOI: 10.1093/carcin/bgn027

[Indexed for MEDLINE]

-Patrick

Myriammole
Myriammole in reply to pjoshea13

can you recommend a specific brand?

pjoshea13
pjoshea13 in reply to Myriammole

Zinc citrate is inexpensive, so there is no reason not to go with the most reliable brand IMO. But there is one big reason to avoid the lesser brands - cadmium contamination. Zinc & cadmium are often found together in the soil. The better brands test each batch.

I suggest:

swansonvitamins.com/nutrico...

-Patrick

Myriammole
Myriammole in reply to pjoshea13

Do you also apply clioquinol?

pjoshea13
pjoshea13 in reply to Myriammole

No. -Patrick

I have been on Clioquinol (plus a zinc supplement) and Cabergoline for about 6 months.

My latest Choline PET scan looked very good - no visible metastatic disease.

I’ve been on multiple treatments so don’t know which or which combination caused the improvement.

Myriammole
Myriammole in reply to andrew61

where do you get clioquinol? how much er day, tablet form ?

andrew61
andrew61 in reply to Myriammole

I use a 4% topical cream applied twice daily. I get it from a compounding pharmacy called Cape Drugs. Prescribed by Dr George Yu.

Myriammole
Myriammole in reply to andrew61

applying it to the area right below the genitals to get nearer to prostate or not? with DMSO or pure?

andrew61
andrew61 in reply to Myriammole

Apply cream to veiny area eg wrists.

I have also used Clioquinol suppositories- get it close to prostate.

sammamish
sammamish in reply to andrew61

Did you note any side effects you might attribute to taking Clioquinol&Cabergoline?

andrew61
andrew61 in reply to sammamish

I did not notice any side effects.

Myriammole
Myriammole in reply to andrew61

thanks. how much cream do you apply, suppositories DIY?

Shanti1
Shanti1 in reply to andrew61

Hi Andrew61,

We are going to try the clioquionol and zinc for my husband with stage IV. How many grams of the 4% cream are you applying daily?

You may also find this excellent article regarding this approach useful:

cancertreatmentsresearch.co...

The author also discusses disulfiram to get the zinc into the cancer cells, but we are going to try the clioquinol first.

Thank you!

andrew61
andrew61 in reply to Shanti1

You should contact Dr Geoege Yu in Annapolis, MD regarding dosing.

He will probably have other suggestions also.

Myriammole
Myriammole in reply to Shanti1

Other zinc ionophores: quercetin, ECGC, best to take together with zinc citrate.

And also : journals.plos.org/plosone/a...

My husband is taking hydroxychloroquine with zinc citrate.

Shanti1
Shanti1 in reply to Myriammole

Hi Myriammole,

We have some clioquinol cream on its way. Regarding hydroxychloroquine, while there is evidence that it has anti-cancer mechanisms, I only see evidence of chloroquine acting as a zinc inophor, not hydroxychloroquine. If you have a reference for hydroxychloroquine acting as a zinc ionophor, please send it my way, if not, you may want to switch to chloroquine or clioquinol, or a combo. Please keep us posted on how your husband responds, and I will do the same.

Warmly, Shanti

Myriammole
Myriammole in reply to Shanti1

oh, you are right! I confound both... chloroquine has more side effects, so I think clioquinol may be the better option. Still not sure about hydroxychloroquine, will try to find out.

Shanti1
Shanti1 in reply to Myriammole

Yes, the chloroquine does have more side effects than the hydroxychloroquine. It may be worth adding to to the clioquinol at a dose much lower than typically used to give a synergistic effect.

Myriammole
Myriammole in reply to Shanti1

Hello! did you get news regarding how much cream clioquinol to apply? The cream I got is 3%.

Shanti1
Shanti1 in reply to Myriammole

In the paper giving the proposed treatment the authors state: "For advanced prostate cancer, the cream could be initially applied to ~2 inch area of skin, perhaps once a day. If no adverse side effects become apparent, the treatment might be increased."

When creams are prescribed it is typically 1g per application. We are applying 1g once a day, but I hope to get my husband to go up to twice a day. Here is some info I posted earlier along those lines. healthunlocked.com/advanced...

I am assuming the cream you have also has betamethasone or another steroid? The systemic absorption of that should be low, but you will want to rotate locations so as not to atrophy the skin. If this works for us we are planning on getting a compounded prescription to avoid the steroid.

This paper gives some useful info on where on the body creams are best absrobed under the "Anatomical Site" section: file:///C:/Users/revot/Desktop/Heather_A._E._Benson_Adam_C._Watkinson_Topical_dosage.pdf.

Myriammole
Myriammole in reply to Shanti1

Thanks! What does 2 inch area mean: 2 in^2 or an area equivalent of 1 inch?

And are you applying just normally or plus an occlusive wrap?

Yes, it has 1% hydrocortisone...

Shanti1
Shanti1 in reply to Myriammole

I'd guess 2x2

Myriammole
Myriammole in reply to Shanti1

thinking about mixing it with DMSO but not sure because of cortisone.

Shanti1
Shanti1 in reply to Myriammole

Adding a little DMSO should help with absorption, which I think is a good thing. There may be some hydrocortisone absorption. 1% would be 10mg per gram, so that would be 20mg applied to the skin per day if you are doing twice a day dosing. The adrenal glands are estimated to make about 20mg of cortisol per day. Since not all 20mg will be absorbed, I suspect it woun't be an issue. In my opinion, it wouldn't be enough to cause cushings symptoms, at most you could get some mild adrenal suppression and would want to taper off if you ever stopped the cream instead of stoping suddenly. Is your husband already taking any coricosteroids, for example prednisone with zytiga?

Myriammole
Myriammole in reply to Shanti1

ok, we will begin without DMSO and later add, my husband is still only with supplements and off-label meds for now, no zytiga.

hansjd
hansjd in reply to Shanti1

Hi Shanti1

I couldn't use the link you posted to check the best locations on the body for transdermal absorption. Can you please give me an idea of what they are? Cheers

Shanti1
Shanti1 in reply to hansjd

Hi-

The order of best absorption from that book was:

Genitals>Head/Neck>Trunk>Extremities

I can't find a link to the paper online anymore, but if you message me your email, I will send it to you. The name of the book is, "Topical and Transdermal Drug Delivery: Principles and Practice"

hansjd
hansjd in reply to Shanti1

Thanks a lot Shanti1. Much appreciated .

JPnSD
JPnSD in reply to Shanti1

Hi Shanti. So I started the 3% Clioquinol Cream (no steroid component - Dermatologist prescribed and compounded locally ($115/90 g tube, and also available OTC in MX as Cortifung at ~$5/30 g tube) on July 15th, 2020. I am applying 2 g/day...mostly on my thighs and buttocks and taking 1-1.5 ml of HYPR Ionic Zinc solution in water/day. Any tweaks that you might suggest to this regimen? I truly appreciate any feedback. I had my PSA done on Day 1 (.08) and intend to take my next reading at the end of August. I am Gleason 9, Stage 4 PC and had RP on 8/2019. Went to< .01 and now at .08 about a year later. Scared to death this is micrometastatic PC as suggested by some on here.

Shanti1
Shanti1 in reply to JPnSD

Hi, I'm glad you were able to find a compounded source. Absorption will be better where the skin is thin and close to blood supply, so think about inner arm, back of knee, trunk (see post above). Also, although we have had some posts on this forum about the HYPR Ionic Zinc, it only has 15mg per dropperful and Costello suggests 50-150mg. We found that the month we used clioquinol without zinc we got no results. Several forms of zinc in capsules are also known to ionize, such as zinc acetate and gluconate. If you want to use the HYPR ionic Zinc, you might consider adding 50mg of zinc to it.

Shanti1
Shanti1 in reply to hansjd

Hi- You can view it here: slideshare.net/drJohanisH/t...

Slide 23.

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