Has Anyone had a CGA CHROMOGRANIN A, EIA Test ? It’s tumor marker test.

[Shorehousejam]

My result, only fighting a year, This is my result from the Chromogranin Test.

My Result is 117 ng/mL

Standard range is 0 - 103 ng/mL

My Chromogranin A result is 117 ng/mL

I Had a prostatectomy, chemotherapy with docetaxel, Firmagon, Zytiga, Prednisone plus Taltz for my sever Plaque Psoriasis, since July 2022. PSA @ diagnosis 942. 40 currently <0.06 ng/mL

I have had blood in stool since July, it’s bright red,

I’m having to wait to see Gastroenterologist until next week.

I was put on Taltz and only on it 6 months and the main side effect is IBS with blood, as noted on line. Three different opinions from dermatologist, primary and medical oncologist if it’s possible that is IBS, from the medication. which I have suffered from, but not with constant blood.

Medications and IBS, Gastric issues also raise CGA.

[Shorehousejam]

Tall_Allen What do you think? Just went for a stool test for parasites and bacteria all negative. I don’t see the H pylori test so I am waiting to see if they tested for that. Can a stool test tell if it’s colon cancer?

[Tall_Allen in reply to Shorehousejam]

The negative predictive value is almost 100%, so a negative stool test is good news. But its positive predictive value is very low, so a positive stool test tells you nothing.

[Shorehousejam in reply to Tall_Allen]

Above is post if you read it, My result, only fighting a year, This is my result from the Chromogranin Test.

My Result is 117 ng/mL

Standard range is 0 - 103 ng/mL

My Chromogranin A result is 117 ng/mL

Is that bad? It’s 14 points higher than standard

[Tall_Allen in reply to Shorehousejam]

So? I don't know why you care.

[Shorehousejam]

my CHA test is high, that’s why I care, I’m concerned as I had my stool tested for an infection and bacteria, they tested everything but the one test my wife wanted which was H pylori, she is asking primary to test specifically for that once again. I’m concerned as my CGA is high, I have 3 lytic lesions and blood in stool consistently as if it isIBS

Once again my wife asked for these tumor marker test the last being the CGA which according to NYP Cornell standards of

Standard range is 0 - 103 ng/mL

My Chromogranin A result is 117 ng/mL

Yes I care

[Lokicliff]

It is used as an indicator for pancreas and prostate cancer[10] and in carcinoid syndrome.[11][12] It might play a role in early neoplasic progression. Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. See chromogranin A GeneRIFs for references. In immunohistochemistry it can be used to identify a range of neuroendocrine tumours and is highly specific for both benign and malignant cells of this type.[13]

Mass spec data shows that several peptides originating from CHGA (163-194; 194–214; 272–295 are significantly lower in samples from ulcerative colitis patients compared to control biopsies.[14]

[Lokicliff]

found that above info. and hope it may help? Honestly, this is all waaaaay above my knowledge, but we are always learning.

[Shorehousejam in reply to Lokicliff]

I just saw your reply…everything helps, thank you so much