Testosterone is increasing? Should I be worried?

[goodgoal]

Hello everyone,

Since my father’s surgery in 2022, his PSA levels have been undetectable. He receives a Zoladex injection every three months. Until this month, the reference range for total testosterone was 1.93 - 7.40 ug/L, and his result was 0.126 ug/L.

This month, the lab's reference value format changed. The testosterone reference range is now 150-684 ng/mL, and his result was 10.17 ng/mL.

What is the difference, and should we be concerned?

[God_Loves_Me]

Testosterone feeds cancer, Testosterone number looks good. many warriors in this group has more than 1 oncologist. Please seek for second opinion as well.

I strongly disagree with dr based on your BIO information.

He should be taking enzalutamide, apalutamide, or darolutamide with ADT. He already had chemo, so he should have more success with ADT+ enzalutamide, or apalutamide or darolutamide

It is also a good time to ask for a PSMA PET Scan as well.

Patient Educations is important. Please read following data

prostatecancer.news/2022/10...

prostatecancer.news/2021/05...

[goodgoal in reply to God_Loves_Me]

Thank you for your response. Testosterone rate < 20 still does not seem to be successful?

[God_Loves_Me in reply to goodgoal]

that's pretty good number. Let me edit my comment

[God_Loves_Me in reply to goodgoal]

He should Also take enzalutamide, apalutamide, or darolutamide with ADT, That's call triplet therapy and also have better result.

[God_Loves_Me in reply to goodgoal]

Does he has any Germline or Genomic Mutations?

[goodgoal in reply to God_Loves_Me]

He has an MSH2 mutation.

[God_Loves_Me in reply to goodgoal]

may be PARP inhibitors also help him in future.

Source :

ncbi.nlm.nih.gov/pmc/articl...

[God_Loves_Me in reply to God_Loves_Me]

Also update your bio with more details so other group member can help you

[j-o-h-n in reply to God_Loves_Me]

Huh? Update? Who's on first?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Still_in_shock]

Move the decimal point over 2 values on the ug/L, that will equate to the ng/mL measurement,

10 ng/mL is castrate level,

[goodgoal in reply to Still_in_shock]

thank you 🙏

[CowBellFever in reply to Still_in_shock]

3 decimal points. 1 ug = 1000 ng

[Tall_Allen]

You wrote: "This month, the lab's reference value format changed. The testosterone reference range is now 150-684 ng/mL, and his result was 10.17 ng/mL."

I think you got the units wrong. His result was more probably 10.17 ng/dL. The previous result of 0.126 μg/L = 12.6 ng/dL, so both are about the same. Anything below 20 ng/dL is excellent.

[goodgoal in reply to Tall_Allen]

Thank you Allen!

[God_Loves_Me in reply to Tall_Allen]

Learning questions - Here goodgoal posted his/her dad only taking Zoladex ever three months and He also completed his docetaxel chemo but did not prescribe him AR at all. do I miss anything ? It is not standard treatment also he has MSH2 mutations as well. What's best thing to do ? i

[Tall_Allen in reply to God_Loves_Me]

In 2021, we didn't have the info on triplet therapy yet. goodgoal had the SOC for newly diagnosed metastatic PCa then which was either ADT+chemo or ADT+Zytiga/Xtandi/Erleada. It is not something that can be changed midstream because chemo (and ARSis) create senescence. While PSA is so low, there is no benefit to adding an ARSi now.

[God_Loves_Me in reply to Tall_Allen]

Thank you so much. 🙏

[addicted2cycling in reply to Tall_Allen]

Remembering the GOOD OLD DAYS (?) back in April 2015 on a Monday urologist tells me SOC is ADT and blah-blah-blah but I said "out with the boys" so 24 hours later they're GONE. 😁

This morning this soon to be 74yo Unique Eunuch got in 31.13 miles bicycle riding with energy gauge on empT

[j-o-h-n in reply to addicted2cycling]

See what miracles you can accomplish when you're no longer distracted playing with your balls....Viva el Eunuch.... Cut em off and donate them for transplanting to ______________________s. (Fill in the blanks)

Good Luck, Good Health and Good Humor.

j-o-h-n