Talazoparib with Xtandi

[revchris77]

All, I’m starting talazoparib 0.5 mg this week in combo with Xtandi and Lupron. I’ve been on Lupron and Xtandi for 7 months without issue. I’m now in progression and hoping talazoparib in combo will help.

Anyone else have experienced this combo?

any advice or things to look out for?

[Graham49]

Thanks for posting. Sorry I can't give you any advice. Please keep us informed about progress of treatment.

[TeleGuy]

Any experience you can pass along? This may be my next step.

[revchris77 in reply to TeleGuy]

I’ve been on talzenna for 3 months now and the med hasn’t been that bad. My RBC went down initially, but after adding omega 3 rich fish into the diet the numbers came up. The biggest issue is some added fatigue. I’ve noticed some body hair loss as well, but nothing off my head.

For me this was a good add. I hope to remain in this combo for as long as possible.

[TeleGuy]

Thanks! Does it seem to be helping the cancer?

[revchris77 in reply to TeleGuy]

So far there are signs. The PSA dropped by half from 8 to 4, and the Alkaline Phosphatase number decreased by over 100 points from 296 to 185. These markers of cancer all happened between the 3 and 7 week mark while on the med. I’m hopeful, but its only been 3 months. My next scheduled labs are in 3 weeks.