As you may know from my previous posts, I've been considering the estradiol patch, as the side effects of 4 years of ADT are mounting. (Spinal Fracture, Osteopenia, Fatigue, bone, joint and and muscle pain as well as general sick feeling. I have discussed on two occasions with my MO, and he is NOT receptive to e2 patch at all. He claims the cardio risks are still present like with oral estrogen. I need recommendations for a more progressive MO. I'm 60 miles Northwest of Philadelphia. My quality of life is diminishing, as I become more afraid of fractures, simply doing day to day activities.
To refresh my status, I was diagnosed in May 2019 stage 4b bone metastases to spine, ribs, neck, skull, shoulders, legs, and hips. Also present was innumerable metastases to the lungs. I started right away on Casodex, then Eligard, Zytiga, and prednisone, and later began monthly Xgeva. Xgeva has since been weened to every three months (April 2022), and within 6-7 months, I suffered my first Vertebral fracture (t-11) compression fracture "Osteoporotic".
I believe from what I've read, that the e2 Patch would give me tremendous benefit. Now I need to find a doctor willing to hear me.
we seem to have similar adt experiences … parallel paths somewhat except for the broken bones ….. so far. After all the great things you hear and see ( Ronron ) on the group, about the e2 patch, I asked my oncologist as well. He was agasp at the question. Said my adt induced cardiac issues were so acute that it was totally out of the question.
All I could think of was : memba that Christmas movie , Christmas Story , where Ralphie wants a Red Ryder bb rifle, and everyone says he’ll shoot his eye out ??? He gets the rifle , finally after much angst, and promptly shoots his eye out !! Yayahahahaya yayahahahaya. Well … just say’in ❤️❤️❤️
When applied on the surface of the skin, as mine is, it goes directly in to the blood stream and bypasses cardiac issues. The information is out there, well documented.
I have been using only the estradiol patches since 8/22 worst side effect is breast enlargement but I consider it minor compared to osteoperosis and the other side effects of the standard ADT treatments. This approach has kept my PSA around 0.05 for the last 21/2 years. If you want to talk about it message me and I will be glad. Most of my history is posted The Patch trail I included is a good trial with good results.
Lance
Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme
I asked my MO about this as I'm considering it & she seemed OK with it. I assume if and when I ask for an Rx for this, she'll still be OK. I go to U of PA in Philadelphia. Dr Naomi Haas.
Have heard multiple recommendations for this doc at Fox Chase Cancer Center at Temple Univ. : foxchase.org/daniel-geynisman ; however, I have no idea about his stance on this issue. I finally was able to convince an endocrinologist to prescribe, but she is still reluctant to give me any E2 dose that causes breast buds or nipple tenderness, even though I tell her that is less of a concern than more fractures.
I have heard that radiation to the breasts can often prevent gynomastica. I think it takes a total of 12 greys, which isn't much. Tamoxifen can also be used if have it.
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Xgeva vs Estrogen Patch against bone loss?
Results of DEXA scan in anticipation of December 12 MO visit. Impression: Bone Density within normal limits. Any reason to add Xgeva?
Estrodiol and PC
