Good morning all. Recently, November 15th 2024, I started a vacation after 7 years of Zytiga, prednisone and Lupron. Overall, I feel like my old pre-cancer self or at least from I remember. About 30 days into my hiatus I weathered a week of entire skeletal joint inflammation. Fortunately, it passed as quickly as it appeared, with the exception of trigger finger in both thumbs and some difficulty in making a fist, I keep thinking (hoping) it will pass but starting to get concerned as golf season is rapidly approaching. Anyone else have this happen to them and if so, suggested treatment options?
As always, thank you in advance for your consideration of this request.
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3putt
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Wow....interesting as I have had exactly the same problem after starting my vacation. Unable to close my right fist like my left and trigger fingers in both hands and feet sporadically, and more often after a round of golf but I have attributed it to other possible causes and an unlikely link with going on vacation. Testosterone is reversing very slowly and currently at 150 or so from near undetectable.
That’s fantastic! Believe it or not my thumbs stoped clicking this morning. I used the therapy dough I mentioned last evening for a few hours and again this morning. And I’m squeezing it right now. Will continue an hour or so everyday and report progress. Best wishes on your journey!
It was on my anniversary of my 7th year of taking the trio. After radiation sessions I met with my oncologist to review results. PSA had dropped and urination returned to normal. I mentioned that after 7 years of treatment I was worn out mentally and physically from the various side effects and elected to stop treatment. My desire for a return, however brief, to the old Dave far outweighed the case for longevity. So far so good with exception of joint inflammation that seems to come and go. My attitude, memory, energy level and sleep patterns enhanced within days and continues to improve. Will it last and for how long nobody knows for sure. And miraculously my thumbs stopped clicking this morning!
I certainly wouldn’t suggest this path to anyone as it’s a personal decision. I wish you the best in your journey!
Interesting to hear this….i have the opposite problem…significant trigger finger and thumb lockup while ON lupron,Abi and pred……perhaps I should get my “thumbs” on some of that putty myself…..it’s getting hard to type on my iPad when my thumbs lock up every 15 minutes or so.
Very well said and important. A lot of folks will read these type of posts with great excitement (myself included). However, as 3putt stated make sure you understand all the details and then determine what is best for you.
not the same situation but my husband is on lupron and Nubeqa he has an incredible amount of joint pain and locking thumb joints. He just had chemo last year and is no where near a adt vacation. His oncologist gave him a small round of steroids to reduce inflammation. It helped but came back after and is the same. She said it’s a side effect of the adt and Nubeqa. I feel like it’s a time accelerator of aging. I hope yours resolves.
I had Trigger finger while ON Lupron a few years ago( not after ) it stopped me exercising i.e. cycling and resistance training. There was no way I could lift weights or grip the bicyle handlebars due to the pain. My GP suggested cortisone injections or wait until it goes away itself. I chose to wait it out, however I put strong cloth Band aids on my knuckles to prevent me using the affected fingers/ thumb. The trigger finger went away eventually after about a month if I remember correctly. Best of luck.
I developed trigger finger a few months ago in my middle finger. I was given a steroid injection in my hand and, so far, it has not come back. If it returns, I can have another steroid shot or two. After that if it returns, they said I would need hand surgery.
Yes, I had trigger finger in one thumb and one ring finger; left hand. I had to get two prednisone (steroid) shots into the joint (really not cool to watch this being done)...after my 2d set of shot the joints are pretty much clear of the trigger finger effect. I also started taking Turmeric Curcumin 500 mg w Black Pepper supplements; it supposed to help w joint inflammation.
My Doctor said if it comes back that he can 'scrape' the passage ways thru which the tendons run, that they are hanging in this area due to deposits and that this would be the next step...but, I have opted to put that off until/ unless the symptoms come back. TNX Rick
Sure did. Actually started back on small dose and seems to helping. Will begin tapering off again im 3 weeks to see if that kick starts adrenal gland. Thanks!
Following on Papa1's post, I experienced similar joint pain/inflammation. Got back on prednisone for a short while and stepped down again. Seemed to help.
same issue - trigger fingers and painful wrist, especially in hand, the region b/w thumb and index finger. I think they called this "De Quervain's Syndrome" or something like that. Cortisone injections have fixed this for me.
Very interested in this conversation flow. I developed trigger finger in both hands and right wrist after my fourth ADT (Lupron) quarterly injection. My team said it wasn’t related to the brachytherapy, EBRT, Lupron, prednisone, etc. but rather something else like arthritis. Was sent to Occupational Therapy for two months and started getting help.
In the meantime I asked a friend, who’s a doctor of pharmacology, what she thought. She sent the following link: inspire.com/groups/zero-pro...
There might be a stronger connection to ADT than we might have thought.
Still have trigger finger, can’t make a fist in either hand, and am now on Celecoxib for the pain and reduce inflammation.
Continue doing my OT exercises but have plateaued on recovery so use weightlifter padded gloves for resistance training, and wrist brace and ring pads at night to stop triggering.
Hopefully as the ADT leaves my body and my testosterone increases things might get better. Any thoughts/comments appreciated.
In December, after a flight, my smallest finger (pinky) became deformed. Literally happened overnight. I'm seeing a hand specialist hopefully in April to understand it more. Really not sure what is going on. Some sign of Dupuytren's contractur, on my other ring finger. I'm on quarterly Lupron, daily Enzalutamide and a weekly alendronic acid pill.
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