Low tumor mutation burden

[wolverine11]

City of Hope performed genome testing from my biopsy from almost 2 yrs ago. Showed Low tumor mutation burden. It says I am not a good candidate for immmune therapy, So I guess provenge would be ineffective. However, found online OS is higher with a low tumor mutation. Not to be confused with low burden prostate cancer. I am high volume stage 4 metastatic. Diagnosed with PSA over 800 with innumerable bone mets Anyone who can provide a better understanding or how to treat much appreciated.

[Blackholes]

Have you looked at the AMG 509 immunotherapy trial?

Another member on this site has had some pretty amazing results.

Read Unknown58,s posts about it.

[wolverine11 in reply to Blackholes]

Thank you, yes AMG 509 looks promising.

[Tall_Allen]

Low mutational burden only means that checkpoint inhibitors (like Keytruda) won't work well. It does not mean that Provenge won't work well, as far as I know. If you have contrary information, please post it.

Yes, it's better to have low mutational burden than high mutational burden.

[wolverine11 in reply to Tall_Allen]

From my biopsy report: Increased TMB may be associated with sensitivity to immunotherapy agents including anti-PD-L1 therapy. The TMB of this specimen is below levels that would predict increased sensitivity to these therapy.....Tall Allen...Thank you

[Tall_Allen in reply to wolverine11]

That doesn't address Provenge. It's really badly written, and I can see why you'd reach the wrong conclusion.

[wolverine11 in reply to Tall_Allen]

Thanks TA...I believe you have posted using provenge in conjunction with radium 223 to increase survival and possibly other scenarios using provenge. Something I would consider suggest to oncologist. I had a slight blip up on last PSA test. trying to prep a plan when eventually resistance sets in. Thanks again

[MateoBeach]

Agree this does not imply that Provenge would not be beneficial for you. I would certainly pursue that and consult about combining it with Ra223 (Xofigo) which provides synergy from the combination.

[wolverine11 in reply to MateoBeach]

Yes I've seen trials posted on here adding provenge to 223 radium increased OS to 19 months...223 alone only 4 month increase. Will bring up....2 years hormone sensitive. However, last blood test slight increase from 0.1 to 0.11 hopefully, it's just a blip, going for blood work today .Thank you