There are several domains, or perhaps I should say tiers, of interest in the overall consideration of men fighting Advanced Prostate Cancer.
The first domain, which is of primary interest to all here, are therapies or interventions that actually fight the prostate cancer. Prostate cancer treatments, including surgical, radiation therapies, hormonal interventions chiefly to disrupt androgen stimulation of PC growth and androgen axis drugs, cytotoxic chemotherapies, immunotherapies, etc. The possibilities are growing and being refined continuously through clinical trials and real-world clinical experience. The expanding, yet ever incomplete, standard of care.
A second domain, in my perspective are interventions, therapeutic and lifestyle which may slow the progression of prostate cancer through ever more advanced stages if invasiveness, treatment resistance, hormone independence and seeding metastasis. These are described in "The Hallmarks of Cancer". Your can see my take in a previous post, of that title.
What is very noteworthy is that ALL of these hallmarks of progression of cancer are driven by the same two factors: inflammation and genetic instability. So I have placed much attention on lifestyle interventions such as exercise, hormesis factors, diet and specific nutritional modifications that can affect these two factors: to attempt to reduce inflammation and promote protection and repair of my genome.
(Note that I consider a 3rd domain to be all of the general healthy practices of life lived to fullness, full of love, learning, friends and adventures. And all I have to give in service to others wherever I can. I always weigh this domain in terms of "Quality of Life". And sometimes the equation ranks QOL and being my best self above "survival in any way, at any cost". But that is a different topic.)
Hallmarks of Cancer: New Dimensions by Douglas Hanahan
aacrjournals.org/cancerdisc...
Many of the same factors that affect cellular mechanisms, regulatory/ signaling pathways and epigenetic mechanisms involved in these hallmarks overlap with the research on longevity and protection from "The Hallmarks of Aging".
My exploration of the research in this field led me to try resveratrol as a dietary supplement. It was part of my personally chosen regimen for a time. But the fact that resveratrol has such low bioavailability in absorption, and rapid metabolism in the gut and in the liver, led me to doubt that it could be effective. So I dropped it.
But now, I have come to be much more interested in the role of a healthy gut microbiome and its interactions with natural, anti-inflammatory, anti-oxidant, anti-microbial, and cellular protective phytochemicals including resveratrol and also quercetin. The evidence favors an emerging view that 1) Healthy gut microbiota may metabolize resveratrol and contribute to its beneficial actions through its metabolites; And 2) that resveratrol has direct effects to promote and protect a healthy microbiome irrespective of bodily bioavailability of the parent molecule.
There are three potential ways resveratrol can affect the gut microbiome: it can make changes to the actual bacteria in the gut, it can modify what the bacteria produce, and it can affect how the cells lining the gut work, as described in a recent review article, the first link below. It is a comprehensive review.
I have attached reference links to two other articles on the topic along with short content quotes. In the meantime, I am adding resveratrol back into my supplement regimen as a "Prebiotic booster or protector". There remains much uncertainty about human applications for conditions like obesity, metabolic syndrome, T2 diabetes, cardiovascular and renal disease. And I am certainly not making any claim that there is a therapeutic effect for resveratrol directly treating prostate cancer. (Domain 1)
But for now it seems to me that the weight of evidence for this very safe plant derived substance may be beneficial for and through a healthy gut. I use 500 mg along with my inulin/FOS prebiotic powder with a high fiber diet and occasion rounds of high quality probiotics. I also take quercetin and a few other plant derived supplements. Please be kind! Paul/MB
Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiotapubmed.ncbi.nlm.nih.gov/291...
Resveratrol is a plant-derived stilbenoid with antifungal and antibacterial properties. It is found in the human diet from various foods such as grapes and the wine produced therefrom, berries such as cranberries and red currants, and peanut skins (1). Interest in the health-promoting properties of resveratrol has been greatly influenced by experiments that have shown an increase in the lifespan of simple organisms by 1) stimulating the activity of enzymes such as AMP-activated protein kinase and the sirtuins that are also activated by calorie restriction (2) and 2) putatively affecting metabolic pathways that modulate molecular damage (3). Interestingly, resveratrol has also been shown to protect against metabolic disturbances induced by a high-fat diet and shows potential in reversing the negative effects of the metabolic syndrome in rodent models (4, 5).
A series of landmark studies has also shown strong cancer chemopreventive activity through the inhibition of cyclooxygenase and anti-inflammatory actions (6–8). The latter has been postulated as the mechanism whereby moderate wine consumption is associated with cardioprotection and other beneficial effects on health, commonly known as the French paradox, a term that refers to the relatively low incidence of coronary artery disease in France despite a high consumption of saturated fats (9, 10).
In addition, direct effects of resveratrol and its metabolites on gut integrity and barrier function have been suggested (17). Broad-spectrum antibacterial activity of resveratrol has been found in several clinically important bacterial speciesResveratrol may thus be able to affect the composition of bacterial species in the gut to one that is conducive to human health.
Resveratrol, Metabolic Syndrome, and Gut Microbiota
ncbi.nlm.nih.gov/pmc/articl...
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy
Poop talk: microbiome and prostate cancer, some news
Radio sensitizers and Microbiome 
