I know some of you have said that you are on Zytiga (Abiriterone) only .
Since it is intended to block the AR pathway (Androgen Receptors) it seems like it is a good candidate to prevent becoming hormone resistant.
it has been shown that nearly all prostate cancer cells depend on androgens and AR signaling for growth. Early in carcinogenesis, prostate cancer cells switch from AR-guided cytodifferentiation of luminal epithelial cells to the AR driving the uncontrolled proliferation of these cells. This switch is a critical event in carcinogenesis, as the AR becomes the primary driver of neoplastic growth in malignant cells.
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I was on the Abiraterone and prednisone for 4 months. It worked at lowering what it was supposed to, it raised my liver enzymes to the point I was taken off for 3 weeks, enzymes went down, then on it for a month and retested. Now I am in limbo waiting for the next move.
Zytiga without Lupron is experimental. I have no idea why you think it delays castrate resistance. If it works, it works only because it also prevents testosterone production in the testicles in addition to the adrenals.
I do not know that it does, I am asking the question.As you probably have figured out Allen, I question every thing and want to know how it works.
By the time I figure out how to not become castrate resistance. I hope to understand PCa as well as you do.
it has been shown that nearly all prostate cancer cells depend on androgens and AR signaling for growth. Early in carcinogenesis, prostate cancer cells switch from AR-guided cytodifferentiation of luminal epithelial cells to the AR driving the uncontrolled proliferation of these cells. This switch is a critical event in carcinogenesis, as the AR becomes the primary driver of neoplastic growth in malignant cells.
The switch they are referring is what I think we call castrate resistance, NO ?
You wrote: "By the time I figure out how to not become castrate resistance. ..."
There's a lot of very smart people working on that problem. If you figure it out, please let us know the answer ;>). I used to think that rocket science was the epitome of complicated science until I read my first books on biochemistry and molecular biology. Having studied philosophy, history, and literature back in school in the 1960s and 70s, I was not well prepared for the new materials. I had to start with pretty basic books.
I think your optimism is justified. If the future is like the past what we'll find is that the remissions last longer and longer, and apply to more and more patients over time. Given the heterogeneous nature of prostate cancer and many other cancers too, it may take a long time before we have every variety of PCa nailed down, but I think it will eventually happen.
Yes I did. We MO did agree to a “break” from Lupron Depot last June ‘21 because with semi-mutual agreement my Cardiac issues were priority One!Ok that is exactly what happened last Fridays’ phone call. That MO’s RN called me personally said Dr Albany can no longer take care of me with my many cardiac arrythmia issues.
Should I be rejected or positive?
Got transferred to a local great Med Onc appt next Thursday.
Yeh and Dr Albany, dont care if I mention his name, had his pre med residency in Cardiology schooling. Yes, he was trained schooled in cardiology first, then moved on to GU medical oncology… Interesting.I still al inclined to message him, his office and try to get a more appropriate “can’t handle me” reasoning.
No it doesn't Eligard is Lupron and Xgeva is for bone strengthening. The Xgeva was stopped after the first year due to Jawbone problems. I've never had anything but Zytiga, Eligard.
I'm on intermittent abiraterone acetate (Zytiga) and dexamethasone. My quality of life is far higher than it was on Lupron, which brought with it "multiple grade 3 toxicities." (Oncologist's words)
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