Time restricted eating and impact of autophagy on prostate cancer

[traveller64]

I have insulin resistance and my physician recommended time restricted eating, 16 to 18 hours of not eating every day to overcome insulin resistance.

I read that time restricted eating induces autophagy. Then I googled "autophagy and prostate cancer" and found these:

"Effective management of prostate cancer requires a better understanding of molecular mechanisms involved in the onset and progression of prostate cancer. Among various mechanisms, autophagy possesses a dual role in cancer, and can either promote or suppress cancer progression."

"In the early tumorigenesis, autophagy, as a survival pathway and quality-control mechanism, prevents tumor initiation and suppresses cancer progression. Once the tumors progress to late stage and are established and subjected to the environmental stresses, autophagy, as a dynamic degradation and recycling system, contributes to the survival and growth of the established tumors and promotes aggressiveness of the cancers by facilitating metastasis. "

I'm not metastatic yet, so if the above is correct, authopagy may suppress my cancer cells for now.

I would like to have your opinion/ experiences on this subject. Thank you

[Nusch]

I’m doing 18:6 since couple of years and all is good. Currently under Lupron and PSA undetectable since 9 months. As PC patient I try to follow a holistic therapy, focusing on PC but not neglecting other diseases such as CV. Time restricted eating hand in hand with a whole food plant based diet plus exercise & mediation is my personal cocktail. Doing well - can recommend.

[Lrv44221 in reply to Nusch]

wonderful Nusch!!!I have read your posts before and they are always correct

The whole food plant based diet along with medatation and excercise is outstanding 🦊🦊

[Hidden in reply to Lrv44221]

Nusch,

Looks like you are doing what I hope to do, only I'm hoping to not have the radiation and ADT my doctor is recommending. Would love to see details of your plan, sounds like it's working.

[Purple-Bike]

Doing 20:4/19:5 for 3 years, I am hoping for autophagy although the strength of the effect with daily fasting is unclear. Some data point to large effects only with multi-day fasting. With my single met spotradiated and with all markers indicating my cancer is senescent, I am betting I am on the right side of the dividing line of autophagy effects. But the kind of research you linked made me not go for 72-hour fasts.

[MateoBeach]

I am another 18:6 TRE ( (or OMAD IMF) most days. Though I am also low carbs with plenty of animal and fish protein as well as veggies and salads. Must be diligent and diversified in your exercise regimen.

Suggest adding Metformin, a well established and safe support against insulin resistance. Peter Attia MD podcasts have very much on this and related topics, “The Drive”. Worth subscribing for a year. Very good discussions with deep dives into the science and the practicalities.

[Lrv44221 in reply to MateoBeach]

yes I agree metformin is wonderful for insulin resistance along with low carbs vegetables and protein 🦊

[traveller64 in reply to MateoBeach]

I'm on metformin since I had psa recurrence 8 years ago. I take 1000 mg x2 daily with no side effects. Does it help keeping cancer under control? It may be helping in my case, who knows? I'm a pt3b and still around, keeping cancer under control with casodex only

[Faith1111 in reply to MateoBeach]

Peter Attia is amazing. I also follow him

[Lrv44221]

interesting and compelling I think the time restriction with your meals is something you have to decide

For me, I really can’t manage it

I have IR too, and use exercise plant based foods and a lot of meditation

But so many people use time restricted eating with great results

I try to help people in here as much as possible

Since I’m female I’m wondering if it matters with IR?

I also keep a daily tabulation of what I eat, exercise etc🦊🦊 that helps me

[dockam]

Hi, I've been doing IF 16:8 since Dx in 2015, also fasted two days prior to each of the 39 chemos that I had. Had very few side effects from both Taxotere and Cabazitaxel, so maybe it helped :-).

I'm coming up on 9 yrs this Oct, so maybe the IF worked in my case and that's what helped me to still be here. Ain't stopping now and of course, as the TV ads say "Individual results may vary"

Sipping my Broth now before my pre Break Fast workout. I use tomato paste, cabbage, curry, garlic, ginger, Shiitake 'shrooms, and dried seaweed in it

healthline.com/health/fasti...

cancercenter.com/community/...

restorativemedicine.org/jou...

Fight on, Fast on

Randy

[Cooolone]

Food lover here... Lol

I try to get the eating down to 8 hours, but it's hard with a lifetime of early (6am) meal and arriving home and eating a late dinner (after 6pm). But I can eat between 9am -5pm, some days I slip, but try to keep it tight. Any less a window will be hard. So 16-8 for now and trying to lower it.

What I eat? Well, in the beginning I too was pre-diabetes, was able to control it via diet. Not so much after ADT which I believe contributed to increased blood sugars. Then added Metformin and that helped but Chemo killed that and was actually pretty bad, blood glucose spiking from simple meals. Added kidney stones popping up that proved to be Oxalate Calcium complicated the problem as what's good to eat for glucose isn't good for Oxalates. A conundrum, but typical of that cloud following me, lol. Changed the Metformin a little and the doc added Ozempic which definitely helped bring the glucose under control but I don't like the drug much and have little weight left to lose. So don't take it weekly, more like every 3rd week and use minimum dose.

Metabolic disease is definitely overlooked by many and the association with our PCa not a subject oncologists pay close attention to. An unfortunate set of events I believe... Ultimately eat, work, exercise, live life in ways that make you smile! Be happy and enjoy! Don't do anything to excess and it will be what it is... I do enjoy my Aged Ribeye still and won't ever give that up ;). But it's not a weekly thing either, lol.

Good Luck

[Rolphs]

Been on 8/16 interval fast since before DX in May 21. Didn't stop APC (GL9, PSA 930. many bone Mets) Currently scans are clean and PSA is .4. I think the fasting has a triple positive role in PC advancement, weight stability and insulin resistance. First time I heard of promoting aggressiveness of existing tumors in late stage but it's something I'll think about if/when my cancer returns. Everything is so damn complicated with this disease. Appreciate the post.

[treedown]

I started 18:6 last fall based on Randy's posts. My doubling time on PSA went from1.3 to 1.8 months. It was all I did so I attribute it to the IF. Other than that it was a rather easy transition for me as work keeps me busy until 11 or 12. The best thing about it was stopping the late night snacks. Soon I hope to be biking regularly and it may need to be modified but has been great for keeping weight down during winter.