My husband has been on Zytiga, Lynparza, Keytruda Docetaxel and now Jentava. He had a bone scan on Mon which showed some progression and the psa continues to rise. His CT scan showed a blood clot in each lung. He went to the er also had a ultra sound of the legs which showed a blood clot in each calf. Was sent home the following day on blood thinners. He was suppose to try a clinical trial PT 112 unfortunately he is no longer eligible for three months due to the blood clots. He has been on 6 rounds of the Docetaxel and 3 of the Jentava. His Oncologist wants to add Carboplatin to the Jentava. I’m concerned due to the fact he has been on chemo for a bit. Would any of you be able to give me some feedback on the Carboplatin? Is it harsh? Also is it harsh on the liver? Very concerned.
Carboplatin: My husband has been on... - Advanced Prostate...
Carboplatin
Did the doctor give a reason for the addition of Carboplatin such as BRCA positive or neuroendrocine differentiation?
No she did not. I did specifically ask about the BRCA she say it is not only used for that mutation. She wants to see if it will slow down the progression.
Adding Carboplatin will generally make the chemo more difficult, but based on what I've heard from others here, still well tolerated by most. How did he do on Docetaxel and Jevtana?
Not to bad. However it’s catching up with him!! Is it hard on the liver?
Not that I know. You could find more details on the prescribing sheet. That shows the results of the clinical trial used to approve it. They will have the percentage of patients that experienced every side effect you can have. Gives you an idea of what to expect.
The main thing to keep in mind is the commitment is only to one cycle, then you can evaluate everything: is it's working, how tolerable were the side effects, what do the liver enzyme numbers look like, etc. Then you can make a decision about going further, stopping, or maybe even proceeding with a lower dose.
You can discuss all of this with the doctor and decide. Personally, I would do it and then see things go but that's me.
Thank you so much gregg57
Carboplatin may affect kidneys and the liver. This link has info from the FDA:
I am the wife of a prostate cancer victim. I unfortunately have had personal experience with Carboplatin, Keytruda and Alimta. Those are a common chemo for lung cancer adenocarcinoma nsclc. I had four rounds at the beginning of my treatment. It stopped my never smoker EFGR positive lung cancer. It is very effective and can have an effect on kidneys but since mine was limited to four rounds it did it’s job and stopped my cancer, now being maintained by Alimta alone. None of this is fun but it does the job. I would ask how many treatments are intended, often it’s between 4-6 with Carboplatin then continuing without the Carbo,
My lung cancer was caused by a melanoma and was treated (13 treatments) with Keytruda and it worked. I gave up smoking many many years ago. You may have or had a melanoma that metastasized to your lungs since you never smoked? Just saying.....
Good Luck, Good Health and Good Humor.
j-o-h-n Thursday 01/27/2022 5:46 PM EST
I have had genomic testing done for targeted therapy. I have adenocarcinoma non small cell lung cancer, not melanoma. I know that melanoma can happen internally as a primary can happen but in my case it is caused from an EGFR positive mutation not smoking. It's almost as complicated as prostate cancer. 😉
I’m currently on Jevtana and Carboplatin although about to stop after 3 cycles since it’s not working for the Mets on my spine. I haven’t found the side effects to be any different than for docetaxel. Take the anti nausea medication- don’t let it get bad.
Early on I had cisplatin, which I understand is similar. It is considered a more ‘harsh’ chemo than docetaxel. Cisplatin was hard for me but also very effective at knocking out he wind out of the sails and getting my dragon back in the cave. My 2c - stay strong
I've read that Cisplatin is more difficult than Carboplatin. It's referred to by some as "sickplatin". It is effective though and often combined with Etoposide for SCLC (small cell lung cancer).
Not to be a pest but I am curious.What is SSLC ?
oops, I meant SCLC (small cell lung cancer)
Mine was combined with etoposide - at initial diagnosis I had a suspected small cell neuroendrocrine component. Talk about being dealt a shitty hand!
I have had ten rounds of docetaxel but no experience with the other drugs. My last three or four rounds were with reduced doses, but I still had good results. However, now I am suffering with water retention and back problems. I can hardly walk, but I am determined with the help of physical therapy and lymphedema therapy to get better. Most of all, I am leaning on the Lord to heal me. He is the great physician.
In spite of the problems I am having, I will most likely be having these other types of chemo that you have described. I really appreciate the information that is being shared in these posts.
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