CHEK2 and Lynparza : Diagnosed three... - Advanced Prostate...

Advanced Prostate Cancer

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CHEK2 and Lynparza

Altamonttt profile image
17 Replies

Diagnosed three years ago. Psa 14.7 and Gleason 9. Have had docetaxel Am on eligard every four months. Xtandi and zytiga did not with for me. Todays bone scan

FINDINGS:

Delayed whole-body planar images were obtained.

Interval significant progression of skeletal metastases is noted.

The number of lesions in the thoracic spine, sacrum, pelvis have

increased in size and number over the interval. Several new

lesions have developed. The lesion in the left scapula and left

proximal femur are redemonstrated.

A new lesion is present in the sternum.

Appropriate renal activity is noted

Recently had genetic testing. Reviewed CHEK2 mutant. MO prescribed lynparza. Any insight on this. Anyone taking lynparza care to comment? TIA

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Altamonttt profile image
Altamonttt
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17 Replies

Good day Altamontt! Welcome aboard .. you’ll get some direct answers from our knowledgeable members . Just call me “ meat head” that Archie Bunker was so dam funny at the time . We really dont have alot of comedy that that any more? Now , Pete Davidson on SNL is a riot . He’s worth checking out on you tube .. .. ...I’m waiting to see what the crew is going to tell you ? We can tell you somethings that the Doctors won’t . . Good job finding this cite . It’s helped me tremendously in the past four yrs that I’ve been a member . My first two years were rough and I had no one to ask . I started this out in 2015 at the age of 53 . We have a brother in arms tradition going on here . We all go through basically the same stuff only at different paces . I think you’ll find a way to push the sucker down some more . Keep swinging ! We can relate to each . Take good care Sir!🏜😎

Tall_Allen profile image
Tall_Allen

The TRITON2 trial of rucaparib found a good initial response in 2 of the 3 men with CHK2, but it was not long lasting. PARP inhibitors are toxic.

Have you tried Xofigo + Provenge?

Altamonttt profile image
Altamonttt in reply to Tall_Allen

No. I haven't tried those. I think from research I I've done, I like the idea of xofigo better than lynparza. Also having stinging various parts of my body from thoracic Mets. Able to do radiation o those while on xofigo?

Thanks for you reply.

Tall_Allen profile image
Tall_Allen in reply to Altamonttt

Yes, you can zap troublesome bone metastases while taking Xofigo. However, it is not always safe to do so - it depends on the size and location. A good RO can look at your scans and determine whether SBRT to those bone metastases is safe (it usually is).

noirhole profile image
noirhole

I just completed 10 sessions od radiation to my spine and sacrum. Tumor was pressing on the spinal cord and causing pain and numbness. Also wanted to take care of it before it traveled to my brain. Good luck!

Altamonttt profile image
Altamonttt

Thanks for your reply. Have planned to talk to RO. Saw a spine specialist a couple weeks ago and he ordered a MRI. Hasn't been scheduled yet.

My husband is starting Lynparza this week. Stay tuned.

2dee profile image
2dee

Yes for a little over 3mos so far.Working really good for me.

Less brain fog, lowered PSA, "feel" better, less pain meds.

I'm BRCA2. On Lupron 3yrs but failing, Xtandi failed after 15mos.

Stage 4 mets throughout, Dx with 1303 PSA in 2018.

Go for it. Don't touch pills with hands. I put in shot glass to administer.

2Dee

konichiwa12 profile image
konichiwa12

Zytiga seemed to work with me for a while until my PSA started going up quickly. PSMA revealed an Oligometastatic lesion in my right Ilium about 6 cm diameter. I had 5 sessions of SBRT which knocked that right back. PSA creeping up again now though so going for another PSMA scan soon (when I get rid of COVID!). Hey ho....

CAMPSOUPS profile image
CAMPSOUPS in reply to konichiwa12

Good afternoon.I don't mean to make light. I sincerely hope you have no heavy covid symptoms and recover quickly.

I must say however you must not be in Japan. Covid is practically non-existent there.

konichiwa12 profile image
konichiwa12

No problem! It’s just like cold as I’m double jabbed and have had booster. I live in Newcastle Upon Tyne so not Japan it’s just where I was working when I joined this site!

CAMPSOUPS profile image
CAMPSOUPS in reply to konichiwa12

I buy Newcastle beer here in the states. Although now days, or for quite awhile really I rarely have even one beer. Anyway can find the actual imported Newcastle and it is better than the Newcastle which is produced in Texas under the Newcastle label.

CAMPSOUPS profile image
CAMPSOUPS in reply to CAMPSOUPS

Enjoyed my work trips to Nottingham back in the old days.The pubs and beer choices were phenomenal.

Many trips and lived in Japan. Hope my trip in 2014 wasnt my last.

ScottfromSD profile image
ScottfromSD

I also have a somatic chek2 mutation and was prescribed olaparib. I quit after a couple months. It didn’t work and made me very anemic. Not a big fan.

Altamonttt profile image
Altamonttt in reply to ScottfromSD

Yeah. Everything I've tried makes me anemic. My blood counts are down slightly all the time. I did start the lynparza today. But I'm wary of it. What did you do after?

Eugmn profile image
Eugmn in reply to Altamonttt

Just curious how the lynparza is working for you?

My husband has been taking Lynparza since January and has tolerated it very well. He's 61. He has the RAD51c mutation. It's rare. All of his siblings have it as well. He had the same problem as you with prior therapies. Lu177 will be the 12th therapy.

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