Finished Xofigo PSA over 800 Oncolgist says time for Chemo also wants us to talk about a trial why would we?

[Yorkielover2]

We have turned down 2 trials in past .My husband wasn’t wanting Chemo but had agreed! I don’t know why we would think about a trial at this point. He has been having more lower back past 2 weeks! Anyone’s thoughts on trial vs chemo.

[tango65]

I would consider the Lu 177 PSMA trials. Lu 177 PSMA treatment has shown to prolong life in heavy pretreated patients and it may be more effective than Jevtana in controlling the cancer for a while.

clinicaltrials.gov/ct2/resu...

There are also trials for Ac 225 PSMA which may be more effective then Lu 177 PSMA if there are many bone metastases:

clinicaltrials.gov/ct2/resu...

[Yorkielover2 in reply to tango65]

Thanks will check those out!

[tango65 in reply to Yorkielover2]

I wish you the best of luck!!.

Lu 177 PSMA does not have major side effects unless there is diffuse and extensive infiltration of the bone marrow by the cancer. They will know about this when they do the PSMA PET/CT before treatment. I had the treatment in 2016, without any problems. I had nodes mets only at that time.

[Yorkielover2 in reply to tango65]

Thank you

[Tall_Allen]

As you know, Xofigo has little effect on PSA. Chemo is good at relieving pain. What trial is it you're considering?

[Yorkielover2 in reply to Tall_Allen]

I don’t know that yet appt on 11/30 .It does involve Taxotere which is the chemo he was to start Dec 6th

[Yorkielover2 in reply to Tall_Allen]

Also having labs for BRAC 1 &2 today at Trial Unit

[NotAlwaysSunshine]

My husband is on Late Chemo. No pain issues so far. We are grateful for his continued quality of life.

[Yorkielover2 in reply to NotAlwaysSunshine]

Late chemo is what?

[NotAlwaysSunshine]

His first chemo was in 2019. The second started about a month ago. My husband failed xofigo in October. Every single MO has a bag of tricks - 2 separate chemos are typically considered.

[Yorkielover2 in reply to NotAlwaysSunshine]

Ok!Mine has not done chemo diagnosed 5 years ago

[dadzone43 in reply to NotAlwaysSunshine]

No: xofigo failed your husband. I hate the implication when doctors say, "you failed A-B-C." Why won't they take responsibility for the failure of THEIR treatment?

[Yorkielover2 in reply to dadzone43]

Our Oncologist did! He called the Radiologist Oncologist to ask him about it! He was upset when we saw him 2 weeks ago and we have had several calls from him on these next treatments! We have no issue with him .

[NotAlwaysSunshine in reply to dadzone43]

He has not responded to anything so far. PSA climbs. Mets increase.

[dadzone43 in reply to NotAlwaysSunshine]

I hope you find a successful path forward

[Yorkielover2 in reply to dadzone43]

Thanks . Time is the goal

[Hidden in reply to NotAlwaysSunshine]

That is my husband also. He has severe pain in his pelvis. Now using a walker. Nothing is slowing this done.

[Yorkielover2 in reply to Hidden]

Sorry to hear! hate this cancer hopefully you have no issues coping with his pain! We have always had meds to help

[cesces]

You may want to consider bipolar androgen therapy.

Try it for a few months to see if it works.

It doesn't work for about half who try it, but when it works it works very well.

[Yorkielover2]

Thank you

[Grumpyswife]

You should feel fortunate to be offered trials. We have been struggling to get my husband into trials for years now.

[Yorkielover2 in reply to Grumpyswife]

We are. We are fortunate to be in Nashville with a great team of Doctors! Does your oncologist not help you find them?

[CAMPSOUPS]

Your assumption is correct. You should not post the name of the place you work for:

FDA Warning Letter to Nutrition 2000

July 19, 2010

Department of Health and Human Services' logo Department of Health and Human Services

Public Health Service

Food and Drug Administration

New Orleans District

404 BNA Drive

Building 200 – Suite 500

Nashville, TN 37217

Telephone: [phone]

FAX: [phone]

June 3, 2008

FEDERAL EXPRESS

DELIVERY SIGNATURE REQUESTED

Nutrition 2000

4108 Rucker Boulevard

Enterprise, Alabama 36330

WARNING LETTER

NO. 2008-NOL-14

Dear Sir or Madam:

This is to advise you the U. S. Food and Drug Administration (FDA) has reviewed your website at the Internet address nutrition2000.com and has determined the products “Cesium and Potassium Combo,” “Curcumin,” “Men’s Prosta-Life,” “PC Hope,” “Platinum,” “Protocel Formula 23,” “Protocel Formula 50,” and “Surcan” are promoted for conditions which cause the products to be drugs under Section 201(g)(1)(B) of the Federal Food, Drug, and Cosmetic Act (the Act) [21 United States Code, Section 321(g)(1)(B)] (21 USC 321). The therapeutic claims on your website establish the products are drugs, because they are intended for use in the cure, mitigation, treatment, or prevention of disease. The marketing of these products with these claims violates the Act.

[Chugach]

I did a clinical trial before my second run at chemo - at some point in this journey I think it is valuable for all men dealing with stage 4 metastatic prostate cancer to consider a clinical trial. It’s the only way to grow the science and help find a cure. The trial I did didn’t work well for me but I’m proud to have helped facilitate the science. It’s certainly an individual decision that depends on many considerations. My 2c

[Yorkielover2 in reply to Chugach]

Thanks for for your post!