Confused and hoping for input

[Tristag]

I’m 68 Diagnosed with Stage IIIc Prostate Cancer 11/2018. Gleason 4+5 PSA 14.51. On Lupron 1/2019 to 1/2020. Zitiga from 1/2019 to 5/2019 (discontinued due to high liver numbers). 28 Treatments of Pencil Beam Proton radiation 3/1/2019 to 4/11/2019. After radiation treatments PSA <.03 from 5/2019 till 8/2020.

11/2/2020 .04

1/5/2021 .07

3/26/2021 .09

5/21/2021 .10

7/16/2021 .08

10/15/2021 .11

Still have Prostate

Have I reached post radiation

Nader?

At what point would I restart ADT if PSA continues to rise?

MO wanted to restart 3/2021 at .09.

Urologist and Radiologist both advise waiting till PSA raises to over .5 then perhaps PSMA.

Is it unwise to wait for it to get that high?

[tango65]

The treatment of radiotherapy for your cancer requieres at least 18 months of ADT (better 2 years of ADT plus abiraterone). You could discuss starting ADT asap.

[Tall_Allen]

Your PSA is supposed to rise as your testosterone returns. If it reaches 2.0, that is called a biochemical recurrence, so you have a long way to go.

[Tristag]

Thanks for the input…I have an appointment with MO Friday to go over test results and talk about future treatment. I am leaning on waiting on ADT …I feel if I restart I will never know if I really need it?

[raoulmaher]

Hi being gleeson 9 myself I would agree with Nalakrats and ADT as I am on xtandi and Zoladex implants and am 0.01 from psa of 41 in just two months although I am led to believe from various that Xtandi can be resisted by the cancer whom find other foodstuffs sugar etc or they make their own testosterone and cause castration resistance - I wish somebody would discover a cure for ALL cancers not just treatments - t cell reprogramming seems to lead the way ! please help us scientific community with a cure - thank you Raoul