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Gut bacteria making hormones

de-luke profile image

Scientists revealed how gut bacteria contribute to the progression of advanced prostate cancers and their resistance to hormone therapy sciencedaily.com/releases/2...

23 Replies

Nice article, thanks for sharing.

I think the microbiome is the next frontier in immunology, buy not in time to help us much. I read through the article but did not see any reference to "good" vs "bad bacteria. Anyone?

kaptank profile image
kaptank in reply to Gudgelm

Ruminococcus bad, Prevotella Stercorea good. However I recollect pjoshea13 (Patrick) posted some months ago on probiotic bugs and came to some conclusions.

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arete1105 profile image
arete1105 in reply to kaptank

That Swansons pre/probiotic is what I take.

TheTopBanana profile image
TheTopBanana in reply to Gudgelm

”Scientists also analysed microbial genetic material from the stool of men with prostate cancer and identified a specific bacterium -- Ruminococcus - that may play a major role in the development of resistance. In contrast, the bacterium Prevotella stercorea was associated with favourable clinical outcomes.”

Ruminoccus produces an inflammatory polysaccharide and is also implicated in Crohn's disease.

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

View ORCID ProfileMatthew T. Henke, Douglas J. Kenny, Chelsi D. Cassilly, Hera Vlamakis, Ramnik J. Xavier, and View ORCID ProfileJon Clardy

See all authors and affiliations

PNAS June 25, 2019 116 (26) 12672-12677; first published June 10, 2019; doi.org/10.1073/pnas.190409...

Edited by Ralph R. Isberg, Tufts University School of Medicine, Boston, MA, and approved

Another paper that might be of interest. The drugs used to treat ruminoccus are stated below.

Ruminococcus gnavus bacteraemia in a patient with multiple haematological malignancies

Caroline Gren, Malene Roed Spiegelhauer, [...], and Leif Percival Andersen

Additional article information

Abstract

We present a case of Ruminococcus gnavus sepsis in a woman suffering from multiple myeloma and myelodysplastic syndrome. R. gnavus , a Gram-positive coccus and a gut commensal, has been described in nine cases of infection in the literature, with most infections having occurred in patients with either gastrointestinal symptoms or prosthesis infections. In this case, R gnavus was identified by mass spectrometry, and showed susceptibility to penicillin, meropenem, tetracycline, metronidazole and clindamycin. The patient was successfully treated initially with intravenous piperacillin/tazobactam and metronidazole, and then switched to oral penicillin and metronidazole. The cause of infection is hypothesized to have been a shift in the gut microbiota towards an excess growth of R. gnavus caused by immunosuppression, and bacterial translocation across a vulnerable mucosal barrier due to prednisolone treatment and severe thrombocytopenia.

tarzantass profile image
tarzantass in reply to Graham49

Can we still take probiotics or yogurt? I think everyone here is eager to know the answer

Our bodies are each a walled garden with a gate to the world. (pardon figurative)

tarzantass profile image
tarzantass in reply to de-luke

Please help us all to clear our doubts as to whether probiotics is bad to take or not

That means we cannot take probiotics and yogurt. Am I right?

NotDFL profile image
NotDFL in reply to tarzantass

No; the study does not lead to that conclusion.

Are they saying that having good bacteria in your gut is bad for us? I am finding this difficult to understand what we could do to help ourselves now.

TheTopBanana profile image
TheTopBanana in reply to Gertabo

I understod it as such: some bacteria (Runinococcus) is bad in regards to hormone resistance. Other bacteria (Prevotella) is the good and has the opposite effect.

Is taking probiotics bad? How about yogurt? Please help us clear this doubt.

Actually, the scientists do not reveal that gut bacteria contribute to the advancement of (castrate resistant) prostate cancer. Right now, it's merely a possibility/hypothesis that needs to be tested.

tarzantass profile image
tarzantass in reply to NotDFL

So it is too early to say probiotics is bad, right? How can something is good to the gut can be bad for the prostate

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You might wait a long time for scientific proof, but there are some encouraging papers, see one below. IMO you need to eat the right kind of prebiotic foods (as per pjosheas posts) otherwise the good bacteria will not last long.

Clinical research Urine ora imbalance and new biomarkers in prostate

cancer and benign prostatic hyperplasia

Shuiping Yin1,2,3, Dandan Xu4, Meng Zhang1,2,3, Peiyu Zhang1,2,3, Yu Guan1,2,3, Julia Kzhyshkowska5, Chaozhao Liang1,2,3

1Department of Urology, The First A liated Hospital of Anhui Medical University, Hefei, Anhui, China

2Institute of Urology, Anhui Medical University, Hefei, Anhui, China

3Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University,

Hefei, Anhui, China

4Department of Oncology, The Fourth A liated Hospital of Anhui Medical University,

Hefei, Anhui, China

5Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim,

Heidelberg University, Mannheim, Germany Submitted: 2 April 2021

Abstract

Introduction: Microbial structure is closely associated with the initiation and development of various diseases. However, the roles of urine flora in prostate diseases, including prostate cancer (PCa) and benign prostatic hy- perplasia (BPH), are still unclear.

Material and methods: In this study, clinical samples were collected from PCa (n = 21) and BPH (n = 19) patients and healthy people (n = 12). The analysis of urine flora DNA sequencing and hematological testing results be- tween groups was performed using bioinformatic methods, including alpha and beta diversity analysis, and functional PICRUSt analysis.

Results: The results showed that the microbial structure in PCa and BPH differed from the healthy control. Abundance of Escherichia coli was higher in PCa and BPH patients, while probiotics, such as Lactobacillus helveticus and Lactobacillus iners, were lower. Moreover, beta diversity in the PCa group was significantly different from the control group, while alpha diversity was not. Spearman analysis showed that Escherichia coli was negatively correlat- ed with Lactobacillus helveticus and Lactobacillus iners. Functional analysis showed that microbial imbalance was associated with energy metabolism in PCa, and with cell motility, energy metabolism, and intracellular traffick- ing, secretion, and vesicular transport in BPH. Moreover, microbial imbalance was associated with nervous disorders and infectious diseases in PCa, and with metabolic system, infectious diseases, and signal transduction in BPH.

Conclusions: Taken together, microbial imbalance may be associated with PCa and BPH. The increase of Escherichia coli was accompanied by the decrease of probiotics, such as Lactobacillus helveticus and Lactobacillus iners. These may be biomarkers for risk prediction and early treatment for prostate disease.

Corresponding author:

Chaozhao Liang Department of Urology The First A liated Hospital of

Anhui Medical University Institute of Urology Anhui Province Key Laboratory of Genitourinary Diseases Anhui Medical University 218 Jixi Road

Hefei, Anhui 230000 China

E-mail: Liang_chaozhao@ ahmu.edu

There has been a bewildering wave of discussion on this subject, and personally I can’t understand where it has practical application or benefits to us. Or maybe I’m just too dense to discern it

NotDFL profile image
NotDFL in reply to Savoy

I agree. Even if we hypothesize that the gut microflora in some individuals makes enough testosterone precursors to overcome hormone therapy (ADT), it still needs to be demonstrated that we can actually intervene by changing the gut microbial flora in a manner that decreases the production of testosterone (precursors). Just adding some 'good' bacteria may not 'work' in men.

I wonder if this is why metformin is linked to favourable outcomes. They don't seem to know how metformin works but it is agreed it changes the gut microbiome...very interesting

So don't run out a get a fecal transplant, just yet. hopkinsmedicine.org/gastroe...

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