Hello fellow voyagers! I have been offered Cabazitaxel in one of three dosages: either 25mg ( FDA original recommendation), 20 ( equally effective as per Firstana Trial ) or 16 ( untested). The choice is mine.
The frequency at my hospital is every 3 weeks. Has anyone had Cabazitaxel on a weekly basis &/or at 16mg?
(History: diagnosed November 2018 with metastatic Stage 4; began Docetaxel November, 2018 with Lupron ( PSA reduced from high teens to .5 ); lupron continues; Jan 2019 began Zytiga which led to doubling PSA most months for 6 months. ; stopped & began Xofigo for three cycles with a PSA at least doubling 2 of 3 months & pain & mets spreading, as per MRI; suspended Xofigo; in one month PSA jumped from 46 to 144 ; about to begin Cabazitaxel. Since had severe side effects from Docetaxel, want maximum brake on cancer but minimal terrible side effects.
Many thanks in advance for sharing your thoughts & experiences. Deeply grateful to all those who have responded in the past.
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baltha
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Excellent Gregg. I did the same. Calculated everything. Thanks to Google and automatic BSA calculators. I have now learnt the formula as well just in case. 😀
Cabazataxel is a rough ride but worked well for me. Ask about reduced doses of both cabazataxel and carboplatin together. Most effective when cancer is stubborn.
I used this drug for one year and it reduced my testosterone to zero as advertised. With my testosterone a zero, I felt like not doing much of anything. It also affected the hormone that causes gynecomastia that makes the male breast grow to some degree while making the nipples sore. After not taking it beyond 12 months, my testosterone came back to low normal, but I still had the issue I just mentioned. I was offered another drug to help regulate the female hormone level to help alleviate the gynecomastia, but I chose not to take it. Instead, I am taking testosterone cypionate 200 at .5 ml per two weeks. Not recommended by some. The breast issue subsided and I have a much more energy now. I play tennis 5 + times per week and feel great.
Sorry but you are going and have been to places, I have not. What do not unferstand, when you were at 12, started Lupron and another, med whise name eludes me at moment, but your results were positive, to go from 12 to.5. Why when things looked as though going well, did you stop what was apparently reducing problems, and change from what was working, and that change resulted in opposite results of I assume you were seeking? Guess I am just really a novice at this ,not at all a game, but don't understand why need to change?Best to all involved.
I just followed my oncologist's lead and simply discontinued Docetaxel after the typical cycle ( about 6 infusions ) and continued on Lupron ADT. He stated he was not concerned as long as my PSA remained below 1.
For almost a year, my PSA remained sub 1 ; then my PSA climbed above 1 but my T remained low ( 5 ). This meant I had achieved mPRPC status ( "castration resistant"). Correct?
At that point, the oncologist suggested Zytiga ( second line hormonal). Since then, it's all downhill so I am returning to chemo ( Cabazitaxel ). Apparently, I may be on it long term but I do not yet understand what that means.
I wish I could offer a pat answer. My husband was dx in 2018 (psa 1,600+) and has been through Taxotere, Zytiga, Xtandi and now back on IV chemo, Jevtana. Lupron all the while. Xtandi was the worst for him as far as side effects. Lupron messes more with his mind, emotions and attitude. After he was off Xtandi, he found he could walk at the gym every day. Even if he didn't want to get up and move, he still went. I'm not saying that was the "cure" but boy, what a difference he feels it makes... dealing with the emotional consequences of the Lupron.
Hope that may have helped some... hang in there! You are loved.
I am not as advanced as you. Was diagnosed 3/2019, PSA 10, 4+3=7 , had a robotic prostatectomy 7/1/2019, Nov Dec 2019 salvage radiation treatments. 3 monthly PSA testing 2020, Sept. PSA began to rise, watched rate of rise. Dec. 2020 had a Pet CT scan @ UCLA , 68Ga-PSMA-11. Result, Low PSMA expression sub centimeter left para-aortic lymph node.
Started Casodex 50Mg, Dec 2020, Lupron shots every 3 months . Side effects minimal, began to have 'hot flashes' , PSA and test. quickly dropping toward 0.
Latest numbers 0n 7/04/2021 , PSA 0.o3, test 7ng. Feel fine, no noticeable loss of energy, (have always been a rather 'relaxed' person). Now just the "wait and see" phase. Hot flashes decreasing now. Just finished a right inguinal hernia repair, easy recovery.
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