Rock on Cabazitaxel!!

[Crummy64]

Dx 18 months ago, becoming mCRPC after only 6 months on ADT, failing abiraterone , failing docetaxel and failing Lu 177 my husband was running out of options. He was in a lot of pain with a soaring PSA - things were looking grim. We had our first visit from the palliative care team two weeks ago. We were not feeling very optimistic (well, I wasn’t!) about the chances of the next treatment - cabazitaxel, commenced 3 weeks ago , doing much. But about a week ago the terrible pain he’d been suffering in his coccyx suddenly started improving and he can sit comfortably again. And blood results today, before his 2nd infusion showed a PSA drop from 86 to 36! So I’m now hopeful he will have a bit more time. Such a roller coaster but we fully intend making the most of the up bits and will be having a trip away from the farm next week😊

[Rob1053]

Wonderful news! Soak up the time!

[noirhole]

I had radiation to my sacrum for pain, since the coccyx is attached it may help. My RO completed 10 rounds. Good luck!

[Crummy64 in reply to noirhole]

Jon had radiation to three areas of his pelvis soon after diagnosis - his pain was severe and he was having trouble walking. The radiation and opioids certainly helped with THAT pain but he developed acute radiation proctitis which was agonising - ‘like passing shards of glass’. I don’t think he’s keen to have any more.

[Hidden]

Glad to hear he is getting a good response from Cabazitaxel. Hope it keeps working. It's not uncommon for PCa patients to get a good pain response from chemotherapy. The first time I was pain free was when I was doing chemo.

There was a clinical trial called the CARD trial comparing Cabazitaxel to switching anti-androgens (Xtandi to Zytiga or Zytiga to Xtandi) and the trial showed better outcomes when going to Cabazitaxel. One of the things they noted was a better pain response:

Pain response could be evaluated in 111 patients in the cabazitaxel group and in 109 patients in the androgen-signaling–targeted inhibitor group. Confirmed pain response was observed in 45.0% of the patients in the cabazitaxel group, as compared with 19.3% of those in the androgen-signaling–targeted inhibitor group (Table S5).

Here's the article:

nejm.org/doi/full/10.1056/N...

[Tall_Allen]

Fantastic! It's great when the drugs finally do what they are meant to do.

[subliminaldood]

Congrats! I'm about to go on that myself, similar situation. BRCA 2 mutation here... which leads to everything (so far) working for a while then not. I've had good luck with RSO or CBD oil for the met pain.

[leebeth]

My husband is about 6 days behind you. His second treatment with carbazitaxel/carboplatin is next Wednesday. He has noticed an improvement in his pain level already as well. I will pray you both keep getting a response! My husband was diagnosed April 1 of last year, so it didn’t take long to fail docetaxel, ADT and abiraterone. Very similar clinical course.

[andrew61]

Cabazataxel plus Carboplatin didn’t work for me. After 2 infusions PSMA scan showed bone Mets continuing to grow. Onto Xofigo I think.

I hope you have continued success.

[HopingForTheBest1]

Thanks so much for your post as I will be starting Cabazitaxel and Carboplatin next week. My first chemo treatment after having had multiple therapies, including participating in several clinical trials that ultimately did benefit me.

[CAMPSOUPS in reply to HopingForTheBest1]

I've kept up with you and have never taken the time to thank you for the trials you have gone into in the past--Thank you.You have been up and down in your PCa I truly hope the chemo puts a dent in your PCa. I have a feeling it will. You haven't had chemo yet and it is often a strong deterrent to our PCa. Again let's hope that's the case for you as well!

[HopingForTheBest1 in reply to CAMPSOUPS]

Thanks so much for your kind words. Greatly appreciated.

[Walkingwell]

Good news, good to hear a positive reaction. Thanks for posting, hope things keep going well.