Dx 18 months ago, becoming mCRPC after only 6 months on ADT, failing abiraterone , failing docetaxel and failing Lu 177 my husband was running out of options. He was in a lot of pain with a soaring PSA - things were looking grim. We had our first visit from the palliative care team two weeks ago. We were not feeling very optimistic (well, I wasn’t!) about the chances of the next treatment - cabazitaxel, commenced 3 weeks ago , doing much. But about a week ago the terrible pain he’d been suffering in his coccyx suddenly started improving and he can sit comfortably again. And blood results today, before his 2nd infusion showed a PSA drop from 86 to 36! So I’m now hopeful he will have a bit more time. Such a roller coaster but we fully intend making the most of the up bits and will be having a trip away from the farm next week😊
Rock on Cabazitaxel!!: Dx 18 months ago... - Advanced Prostate...
Rock on Cabazitaxel!!
Wonderful news! Soak up the time!
I had radiation to my sacrum for pain, since the coccyx is attached it may help. My RO completed 10 rounds. Good luck!
Jon had radiation to three areas of his pelvis soon after diagnosis - his pain was severe and he was having trouble walking. The radiation and opioids certainly helped with THAT pain but he developed acute radiation proctitis which was agonising - ‘like passing shards of glass’. I don’t think he’s keen to have any more.
Glad to hear he is getting a good response from Cabazitaxel. Hope it keeps working. It's not uncommon for PCa patients to get a good pain response from chemotherapy. The first time I was pain free was when I was doing chemo.
There was a clinical trial called the CARD trial comparing Cabazitaxel to switching anti-androgens (Xtandi to Zytiga or Zytiga to Xtandi) and the trial showed better outcomes when going to Cabazitaxel. One of the things they noted was a better pain response:
Pain response could be evaluated in 111 patients in the cabazitaxel group and in 109 patients in the androgen-signaling–targeted inhibitor group. Confirmed pain response was observed in 45.0% of the patients in the cabazitaxel group, as compared with 19.3% of those in the androgen-signaling–targeted inhibitor group (Table S5).
Here's the article:
Fantastic! It's great when the drugs finally do what they are meant to do.
Congrats! I'm about to go on that myself, similar situation. BRCA 2 mutation here... which leads to everything (so far) working for a while then not. I've had good luck with RSO or CBD oil for the met pain.
My husband is about 6 days behind you. His second treatment with carbazitaxel/carboplatin is next Wednesday. He has noticed an improvement in his pain level already as well. I will pray you both keep getting a response! My husband was diagnosed April 1 of last year, so it didn’t take long to fail docetaxel, ADT and abiraterone. Very similar clinical course.
Cabazataxel plus Carboplatin didn’t work for me. After 2 infusions PSMA scan showed bone Mets continuing to grow. Onto Xofigo I think.
I hope you have continued success.
Thanks so much for your post as I will be starting Cabazitaxel and Carboplatin next week. My first chemo treatment after having had multiple therapies, including participating in several clinical trials that ultimately did benefit me.
I've kept up with you and have never taken the time to thank you for the trials you have gone into in the past--Thank you.You have been up and down in your PCa I truly hope the chemo puts a dent in your PCa. I have a feeling it will. You haven't had chemo yet and it is often a strong deterrent to our PCa. Again let's hope that's the case for you as well!
Good news, good to hear a positive reaction. Thanks for posting, hope things keep going well.