has anybody with advanced PCa got twitchy wrist. By this I mean a tendency for a wrist to vibrate like you see in Parkinson sufferers. When my arm is hanging loosely, e.g. when I am walking, my right wrist starts spontaneously vibrating and I have to clench my fist to stop it. This started quite suddenly a month or so ago. The question is, could this be a side effect of any of the supps and drugs I am taking? Onc says zytiga not the cause (I have been on it for 21 months), COC say their drugs (metformin etc) very unlikely to be the cause (been on them for a year), and I am on many of the Jane McLelland recommended supps: berberine, curcamin, low dose aspirin, loratadine, HCA, quercetin, ursolic acid, resveratrol, NAC, symprove. Problem is only in one wrist, tho there is a tendency for my ankles to vibrate when I am sitting. I really really don't want to contemplate Parkinsons on top of PCa! Any guidance welcome
Spontaneous twitchy wrist: has anybody... - Advanced Prostate...
Spontaneous twitchy wrist
I listed all my current drugs in my post, except for the 4 COC ones, metformin, atorvastatin, doxycycline and mebendazole. Awaiting blood test results right now, and will discuss in a few days with onc and GP. Nothing badly out of the ordinary when I ran the last test 4 weeks ago past my COC doc - the main anomalies being PSA 170 and rising and ALP 580 and rising, both more linear than exponential.
It is possible that it is neurological. My brother had something similar -- and before he knew he had prostate cancer. In fact, it is how it was diagnosed. He had an MRI which showed an issue on his cervical spine. He had radiation which shrunk that tumor and the wrist symptoms went away. In his case, first he had the symptoms in 1 wrist and within a month or so, the other. Good luck.
One sure way to tell- stop taking all supplements for 2 months, and see if it goes away.
I thought I had replied, but it seems to have disappeared.
This sound a good idea, which had crossed my mind. But I am worried about stopping supps for 2 months, cos PSA and ALP are starting to rise faster and are already high.
In last 4 weeks PSA has gone from 170 to 200 and ALP from 580 to 808. Faster than linear but not yet exponential.
Does it need to be as long as 2 months?
Your supplements probably aren't doing anything other than giving you a greater sense of control (which is a good thing). I don't know about the water/fat solubility of all those supplements, and their serum clearance rate. Most fat soluble drugs can take a while to clear if they are stored in fat and the liver. Even 2 months may not be enough - but if your symptoms abate sooner, you'll know sooner. With your ALP rising that fast, there is a concern that one or more of those may be damaging your liver.
well my monthly blood tests are to check liver and kidney function, both OK so far, but will hear what onc says this week. I am certainly tempted to stop for a while.
If your ALP is at 808, your liver function is not OK so far.
I have stopped all supps from yesterday, so let's see what happens. Thanks for the suggestion
when I was first dxed in Oct 2017, my ALP was 2325, and bone scan showed bone mets all over, indeed there was a flap about possible fractures. So there has been signif bone activity for 2.5 years. PSA was 960.
ADT and maybe doxycycline brought both measures down, to 92 ALP and 1.8 PSA, but in late 2018 they shot up over 2 months to 3468 and 600. Onc hastily put me on xytiga, and within weeks PSA dropped to 22 and ALP reached a min of 141 in June 2019. Since then they have gone up slowly despite my adding Jane McLelland supps and Care Onc Clinic drugs. Now they appear to be going out of control, and I do not know what to do next. Have not done intravenous vit C yet tho.
The Holy Grail
COVID-19, and PCA 
Interesting study on combination of statins and metformin in high-risk patient outcomes
Blood pressure medications and prostate cancer
