is there a drug against high blood pressure that at the same time is useful against PCa?

Since my husband probably will have to take drugs against high blood pressure when on ADT, is there anyone that is also proven to be useful against PCa?

[pjoshea13]

Looking at the ABC of hypertensive-PCa studies - ACE inhibitors, Beta blockers & Calcium channel blockers - there is a possibility that beta blockers might affect PCa outcome.

In a 2015 meta-analysis [1]:

"These findings indicate that beta-blocker use was associated with reduced cancer-specific mortality among prostate cancer patients taking beta-blockers."

but, in a large UK study [2]:

"Beta-blocker usage after diagnosis was not associated with cancer-specific or all-cause mortality in prostate cancer patients in this large UK study."

-Patrick

[1] ncbi.nlm.nih.gov/pmc/articl...

[2] ncbi.nlm.nih.gov/pubmed/247...

[podsart in reply to pjoshea13]

Any info re Losartan with regards this synergy possibility?

[pjoshea13 in reply to podsart]

A negative study (cancer incidence):

ncbi.nlm.nih.gov/pubmed/213...

However, there are positive mice/cell studies, eg.:

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/268...

-Patrick

[podsart in reply to pjoshea13]

Thanks Patrick; u r amazing

I will read these

I am still studying the articles u sent on methylation—prob will need to ask a question or 2 ; those will require 2 reads to begin to comprehend

[j-o-h-n in reply to podsart]

To pods art

"Thanks Patrick; u r amazing"

Everyone on here is amazing except me (I'm funny sometimes).

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 03/18/2019 3:50 PM DST

[Hidden in reply to j-o-h-n]

John, you are amazingly funny.

I am neither amazing nor funny.

[j-o-h-n in reply to Hidden]

Whoa Whoa Nellie...... Thanks but you must be pulling my chain......That's okay I like it when people do, keeps me on my toes...After viewing your 125 page book on your Pca experience you are amazing.

Would you mind it if I write a subject here on H.U. regarding your free book on Pca details/accomplishments? Please let me know. Thank you!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 05/06/2022 2:57 PM DST

[Hidden in reply to j-o-h-n]

I'd really like that John. Thank you, kind sir.

The only reason that I wrote that book is to help others. SOC can be great for many but some of us are ready to throw in the towel (3 years ago I was one of them but have a family so had no choice other than to look for other options). At the very least the therapies I've done make me strong enough to think about RT.

I'm going to add some more info stressing SOC therapies. No details but stress the importance and point people to informative books and websites.

[NPfisherman]

Patrick is correct about beta blockers... propranolol is currently in a study... if your man is on abiraterone, then there may be some synergy with Norvasc or amlodipine--CCB--there are drugs which interact to prolong the effect...it is listed among them...although strength of synergy is unknown to me...

Fish

[Tall_Allen]

So far, there is only equivocal observational evidence. As many studies show no benefit as show benefit, but that's only because of considerable selection bias in all of them. But I don't think there is any harm to taking them.

There are a couple of clinical trials of beta blockers for PC:

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

[herb1]

There have also been a few studies(?) that suggested doxesozin (cardura). Try Ng, Bales, Box, et al, Proc Annu Mtg Am Assoc Cancer Research 38:A615, 1997. Also see Uemura, et al, J Clin Oncol (mtg abst) 22:4614, 2004.

[Kevinski65]

I'm on atenolol... stage 4, M1, PSA 31 at dx, Gleason 9, 7 years out. . I have hyperthyroidism do I have to take a beta blocker for blood pressure. I also have to take tapazole for hyperthyroidism. I've read that it slows down PCa.