DX 2014: GL9, 3.32 (high Gleason, low PSA; PSA not always a good indicator)
Cue the trumpets: Two weeks after my 76-year old husband completed 10 Docetaxel infusions, his bone and CT scans show that his mets remain stable. They have now been stable since October, 2019 when he started the chemo slog after Zytiga failed within four months. The 10th chemo infusion was 5/25/20.
Per Dr. Matthew Smith at Mass General, coordinating with our local MGH oncologist, my husband received 7 full doses of Docetaxel then 3 doses @ 75% strength. The infusions were the usual three weeks apart. (Anyone else on HU get this kind of full-strength, then reduced strength combo?)
He still has some residual neuropathy despite icing of hands and feet. He hopes to feel less tired soon, though fatigue doesn’t deter him from doing regular 20-25 mile bike rides several times a week. Like many guys here, he stays in good shape so he can get really sick! He’s still on Lupron, getting Xgeva, and weaning off Prednisone.
PSAs since 10/2019: .66 .69 .77 (chemo started) .60 .51 .39 .32
ALPs since 8/2019: 173, 42, 42, 39, 40, 39
SCANS:
10/21/19 right before chemo: Bone scan: "Appearance generally similar to 8/19 scans.”
CT scan chest, abdomen, etc: “Abdomen pelvis: no evidence of metastic disease in pelvis, abdomen; possible liver cysts”
3/2/2020 "generally stable" PSA still low; liver cysts shrunk so possibly they were liver mets
6/3/20:
Bone: “Stable appearance of the skeleton with multiple areas of skeletal metastatic disease in the spine and pelvis but no evidence of new or clearly progressive disease.”
CT chest, abdomen, etc. “No evidence of progression of disease.”
Will get scanned again in three months. Thank you all for your encouragement and advice throughout the chemo. Have a good weekend.
What next? Abiraterone->Docetaxel->Cabazitaxel-> ?
Docetaxel Failing
Docetaxel 
Timing of Docetaxel
