Status update

[chascri]

2020 The Arbiterone I started in July has stopped working. My last set of scans in February showed tumors stable with no new Mets. PSA back up to 15.7. My medical oncologist has recommended in-home hospice. I enrolled this past week. I am now on Palliative care only. A summary of my treatment since diagnosis in 1999 is in my profile. I hope it is helpful to others recently diagnosed as to what the future may hold.

[Longterm101]

How about some LU177 and get another run at life !?

[Hidden]

What an *amazing* fight you put up. You didnt cede an inch, not one damn inch! There were no complaints and all the info you shared. There is never a good thing to say when you read these statuses, but I am in awe sir.

[tango65]

It seems you never had chemotherapy.

You could discuss doing chemo with docetaxel or cabazitaxel and direct biopsy of the metastases to study the genome of the cancer and try to determine if there is neuro endocrine PC.

If direct biopsy is not possible they could do a liquid biopsy to study circulating tumor cells or free DNA particles. With a PSA of 15 and multiple bone metastases the liquid biopsy could have a good yield.

If they can study the genome, the cancer could have mutations such as BRCA, ATM, MSI-H, MMRd etc which could be treated with drugs such as Olaparib or Keytruda or similar drugs. If there is a neuro endocrine component they could try cabazitaxel plus cisplatin chemotherapy.

Then there is the possibility of getting treatment with LU 177 PSMA and Ac225 in Germany if financially possible.

There is a clinical trial for AC 225

clinicaltrials.gov/ct2/show...

and for Lu 177 PSMA:

clinicaltrials.gov/ct2/resu...

[tallguy2 in reply to tango65]

I agree. Are you healthy enough to take a run at chemo? That would be the next logical step where I in your position.

[Schwah]

We gotta great group of men here. Always looking to help. It amazes me and restores my faith in mankind. 😁

Schwah

[monte1111]

Hoping you can get out of that wheel chair. This all sucks. You have done so much, for so many years. Hoping they can try something.

[j-o-h-n]

You've been fighting those tiny M.F. bastards for 20 years. I wish I could recommend something so that you can be fighting them for another 20 years. Just laugh if you can and I hope and pray you stick it out and win the battle. God Bless...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 03/01/2020 9:38 PM EST

[chascri]

Thanks. The battles are over now. I look forward to boldly going forth to where all men have gone before. I just hope it is sooner now rather than later. May the force be with you

[jtspitfire]

God bless you....your courage is remarkable.

[timotur]

Thanks for sharing your story, you've fought a good fight and handled it well.

[Union98]

Sending positive thoughts and prayers that you meet the next challenge with grace and courage, which you have an abundance of.