The CDC, the NIH and even Fauchi seem determined to run behind the curve of the best available information. But must face the facts of the need for a booster after six months. Perhaps it will become available by September?
In the meantime on a personal note, my wife recovered smoothly and progressively after 9 to 10 days of suffering. I had more extreme symptoms with an incredibly painful and swollen throat and could not hardly swallow anything, including sips of liquids and take meds. Fevers headaches and body aches persisting. I finally self-diagnosed myself with COVID epiglottititis based on the symptoms, then confirming by putting fingers down my throat and feeling the poor swollen thing. (Cases are reported in the literature). I received the Regeneron monoclonal antibody infusion on Friday with no noticeable initial effect. So I decided to start on dexamethasone Saturday evening along with amoxicillin and promptly began to markedly improve. (4 mg dexamethasone twice daily.) such a relief!
Text of release July 28, 2021—New York—Pfizer posted data on a third, booster dose of the Pfizer/BioNtech vaccine, to be given at least 6 months after the second dose.
Antibody levels against the Delta variant in patients age 18 to 55 years who receive a third dose of vaccine are over five-fold greater than those following a second dose. Among patients age 65 to 85 years who receive a third dose, antibody levels against the Delta variant are over 11-fold higher than following a second dose.
The data, which have yet to be peer-reviewed and published, cite an "estimated potential for up to 100-fold increase in Delta neutralization after vs before the third dose."
Antibody levels against the original coronavirus variant and against the Beta variant, first identified in South Africa, were reported to be five to 10 times higher after a third dose than after a second dose.The tolerability profile of the third dose is consistent with that of the first two doses.
Data are from the global phase 3 portion of the clinical evaluation of the efficacy, safety, and tolerability of a third dose of the vaccine vs placebo. The efficacy of the third dose on continuing to prevent COVID-19 infection is being evaluated. The phase 3 study will enroll 10,000 participants from the original phase 3 trial.
Pfizer set off alarms by releasing data on a third dose prior to informing the CDC and NIH and has apologized.
Anthony Fauci, MD, Director of the National Institute for Allergy and Infectious Diseases and chief of the Laboratory of Immunoregulation, told CNN viewers to “listen to the CDC and not Pfizer when it comes to needing a Pfizer vaccine booster.”
Peter Hotez, MD, PhD, of the Baylor College of Medicine, Houston, told CNN viewers, “In the UK, Scotland, and Canada there are now three studies showing >80% protection, so pretty close to what we’ve seen. That’s the reason why we don’t need to be concerned right now about getting a booster.”
Reported protection against the Delta variant has been reported at 72% after one dose of the Moderna vaccine and 64% after two doses of the Pfizer/BioNtech vaccine. More data is needed on the protection afforded against the Delta variant by the Johnson & Johnson vaccine.
Pfizer and BioNtech expect to publish more definitive data about the analysis and to share all accumulated data as part of ongoing discussions with the FDA, EMA, and other regulatory authorities in the coming weeks. Application for emergency use authorization in the US is planned for August.
Regulators will determine whether, and which populations, may need a third dose of the Pfizer/BioNtech vaccine. If recommended, immunocompromised, older adults will receive it initially.
According to data published on July 20, 2021 by the CDC, emergence of the Delta variant, and associated rapidly increasing infections, represent approximately 83% of sequenced cases in the US.
First, I am happy that you are recovering. Great news!Second, thanks for posting your treatments.
Third, based on the available data a booster would seem wise. I hope the CDC recommends it if further data warrants it. I do agree with their opinion that the manufacturer of a drug shouldn't set policy for that drug. At the same time I think that in cases like these the CDC and the government should be proactive rather than reactive.
The 4 mg dexamethasone twice daily took the swelling down ..... when you go off dexamethasone, I suggest you, as much as possible, taper the dose ..... I know it is a small dose but I believe larger doses are tapered & it will make it easier on your body.
Israel probably had one of the best vaccine roll outs in the world and their studies show waning immunity after 6 months so they have already started offering boosters to their population. I don’t understand the hesitancy of offering a booster to the “at risk” community in he US. To me it seems that they’re worried about the PR of a booster shot being required as they struggle to get the first shot into people, which is ridiculous. 80% is fine but I’d feel a lot better knowing my protection is ramped up again and strong. I’ve got my sleeve rolled up and I’m ready, let’s go!
You are right it was very dicey. Wife wanted to take me to hospital. But knew I’d end up intubated. Had the dexa in reserve when I confirmed the diagnosis. Couldn’t swallow but could still breathe so started the dexamethasone. Fortunately it workedQuite promptly. The difference between a big adult larynx and a tiny child’s. Now That is truly terrifyingly.
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