I was DX 7+ years ago with metPC. I had mets in 2 vertebre, my left acetablum (hip), one lymph node and possibly 2 ribs. I was treated with Lupron and Zytiga INTERMITTENTLY for 5 years, during which I had 3 "vacations". I also had my prostate removed (along with more than 30 lymph nodes (of which only one was :dirty". Early on and I had radiation to the large tumor in my left "acetablum" (i.e. hip). A new doc took over my case 2+ years ago and stopped giving me the Zytiga. Alas, a few weeks ago, my PSA became measurable at for the first time while under treatment. Of course, it also eventually would become measurable at some point when on "vacation", which is why I always had to revert back to treatment. My PSA rose from .08 to .12 quickly (I think it was 2 weeks). I went on Zytiga again, for the first time in 2+ years. PSA dropped from .12 to ,10 and then again to .08 in subsequent 2 week periods. It was .08 again 2 weeks later and went UP to .10 last week. So- I am wondering if ADT (Lupron and Zytiga ) is no longer working. My doc wants to continue to test my PSA in the coming weeks and scan me in 6 months. She doesn't presently plan on changing treatment AT THIS POINT, as I remain mostly asymptomatic. IFFFF my PSA continues to rise, I think I should be scanned much sooner than 6 months and if the cancer has progressed on scan (and even if it hasn't) I wonder what are the next steps I should consider. Docetaxel? LU-177? Something else? Exceot for the PC, I am other wise healthy except for some orthopedic issues) and only 61. No heart issues.
One other thing- I just started getting some neuropathy in my left leg, mostly in my shin area. Any suggestions to improve that would also be appreciated.
Apologies for such a long post/